The 19th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD)

Coming Soon...

GHS 2023

JOHN C. MARTIN TRIBUTE (10:45 - 11:00)

Michael Manns

Germany

WHO SYMPOSIUM

Viral Hepatitis Elimination What’s new, what’s next, what’s missing in WHO guidance (8:30 - 10:30)

Moderators:

Meg Doherty

WHO Switzerland

Setting the scene-what’s new – evolving global perspective and hepatitis strategy (8:30 – 8:40) + Q&A (8:40 – 8:45)

Meg Doherty

WHO Switzerland

Next steps for validating progress of the hepatitis response & Path-to-Elimination (PTE) (8:45 – 8:55) + Q&A (8:55 – 9:00)

What’s new and what’s next- Simplified service delivery for adults & children with hepatitis B and C (9:00 – 9:10) + Q&A (9:10 – 9:15)

Reaching hepatitis elimination in key populations and PWID (9:15 – 9:25) + Q&A (9:25 – 9:30)

Niklas Luhmann

Switzerland

Towards 2030 elimination: Data for person centered care, hepatitis cascade and mortality impact (9:30 – 9:40) + Q&A (9:40 – 9:45)

Catherine de Martel

Diana Faini

Facilitated panel discussion – Looking ahead to 2030: What’s missing (9:45 – 10:15)

Country perspectives – HCV self-testing: Saeed Hamid (Pakistan)
Implementing partner: Oriel Fernandez (CHAI)
Community perspectives: Su Wang, World Hepatitis Alliance (WHA)
The financing gap: Finn Jarle Rode/Maria Salazar, (The Hepatitis Fund (THF))
Coordinated public health responses from Countries: John Ward (CGHE)
Data to measure and drive progress: Homie Razavi (CDA Foundation)

Closing reflections and way forward by Margaret Hellard (10:15 – 10:30)

Late-Breaker Abstracts Session

(16:30 - 18:30)

Moderators:

Late-breaker abstract: Depletion Of Dipeptidyl Peptidase 9 (Dpp9) In Hepatocytes Increases Beclin-1 And Activated Caspase-1 Protein Levels In An Experimental Model Of Hepatocellular Carcinoma (16:30 – 16:40) + Q&A (16:40 – 16:45)

Mark D Gorrell

Late-breaker abstract: Preclinical Antiviral Profiling Of Ab-161, An Oral Hbv Inhibitor That Destabilizes Hbv Rna And Suppresses Hbsag (16:45 – 16:55) + Q&A (16:55 – 17:00)

Angela M Lam

Late-breaker abstract: Efficacy And Safety Of Talen®-Mediated Genome Editing Of The Hepatitis B Virus Cccdna And Integrated Dna In Vivo (17:00 – 17:10) + Q&A (17:10 – 17:15)

Ramon Diaz Trelles

Late-breaker abstract: Are Hepatitis C Virus Core And Ns5a Polyamorous? Host Interacting Partners Identified In An Infection System (17:15 – 17:25) + Q&A (17:25 – 17:30)

Angeliki Anna Beka

Late-breaker abstract: Hepatitis Elimination In Context Of Pandemic Preparedness And Response – Opportunities To Strengthen Health Systems (17:30 – 17:40) + Q&A (17:40 – 17:45)

Nida Ali

Late-breaker abstract: The Impact Of Covid-19 Outbreak On The Elimination Of Hepatitis C In Taiwan (17:45 – 17:55) + Q&A (17:55 – 18:00)

Wen-Wen Yang

Late-breaker abstract: Real-Time Monitoring System For The Progress Of Hepatitis C Elimination: The Experience From Taiwan National Hepatitis C Elimination Progress Monitoring Information Network (Twnhcp-Min) (18:00 – 18:10) + Q&A (18:10 – 18:15)

Wen-Wen Yang

Late-breaker abstract: Update On The Hepatitis C Care Cascade And Progress Toward Hepatitis C Elimination In The United States In 2021 (18:15 – 18:25) + Q&A (18:25 – 18:30)

TUESDAY, APRIL 25, 2023

12:15 - 13:15 - INDUSTRY LUNCH SYMPOSIUM

Presented by

Title: GSK Looking to the future of hepatitis B: Why should we aim for functional cure?

Join our esteemed panel of experts to explore the real-world unmet needs for people living with chronic hepatitis B and understand the potential impact the advent of functional cure could have at the level of everyday patient care.

Speakers: 

Danjuma Adda is a Hepatitis B patient, advocate and a voice for poor populations. He was infected with Hep B while in clinical rotations and then lost his own mother to the disease several years later. He has a background in microbiology, and an MPH, with over 15 years-experience in public health and advocacy. Danjuma in 2021 assumed the role of President, World Hepatitis Alliance (WHA), UK. His local charity in Nigeria also works in the area of HIV/AIDS prevention and care, patient safety and antimicrobial resistance and stewardship in Nigeria, working to raise awareness and health care worker’s education to reduce the burden of antimicrobial resistance in Nigeria. Danjuma is a Senior Fellow with ASPEN Institute, US; Technical Advisor/Member of the World Health Organizations (WHO) Strategic and Advisory Committee on HIV, Viral Hepatitis and STIs (STAC-HHS); Executive Board Member Coalition for Global Hepatitis Elimination (CGHE) at the Global Task Force for Hepatitis US CDC; Member AMR Advisory Group of the AMR Patient Alliance; and member of several global networking groups and an accomplished Public Speaker. Danjuma is a leading voice for Hepatitis patients in Nigeria and uses his platform to advocate for the most vulnerable populations across Africa. Danjuma wants to change the narrative about Hepatitis and raise awareness about the deadliness of the disease, while also promoting other health outcomes such as antimicrobial stewardship and patient safety.

Dr Chari Cohen is President of the Hepatitis B Foundation. For the past 22 years, she has planned, implemented and evaluated community programs and research projects focusing on reducing health disparities and improving health outcomes associated with hepatitis B and liver cancer. Dr. Cohen is co-chair of the national Hep B United coalition, co-founder and chair of Hep B United Philadelphia, co-founder and chair of CHIPO: Coalition Against Hepatitis for People of African Origin; co-chair of the Hep Free PA coalition; and chair of the Sidney Kimmel Cancer Center Community Advisory Board. She is a member of the ICE-HBV steering committee, the HepVu advisory committee, and is a member of the HBV Forum for Collaborative Research and the Patient Advocacy Group of the American Association for the Study of Liver Diseases (AASLD). Dr. Cohen is Professor at the Baruch S. Blumberg Institute, and adjunct faculty for Geisinger Commonwealth School of Medicine. She received her DrPH in Community Health and Prevention from Drexel University and her MPH from Temple University.

Dr Ahmed El Sharkawy has been a consultant transplant hepatologist at the Queen Elizabeth Hospital in Birmingham since 2012. He is also honorary senior lecturer at the University of Birmingham and a Fellow of the Royal College of Physicians of London. His clinical interests include viral hepatitis, liver transplantation, polycystic liver disease, drug induced liver injury, primary biliary cholangitis, acute liver failure, acute on chronic liver failure, NAFLD (especially in the context of hepatitis B) and cirrhotic sarcopaenia. He has pioneered novel approaches to the management of hepatitis C in the community. He was awarded his PhD from Newcastle University on the role of NF-kB in the hepatic inflammation-fibrosis-cancer axis. He is a research active NHS clinician and is PI on a number of trials including a NIHR Liver Research Partnership on HBV Patient Engagement. He is the EASL Internal Affairs Councillor, Treasurer of BASL and Clinical Lead of the BASL HBV SiG. He is keen on promoting the role of social media, in particular Twitter, in medical education.

Professor Victor de Lédinghen MD PhD is Professor of Hepatology and is currently Head of the Hepatology and Liver Transplantation Unit, Haut Lévêque Hospital, University Hospital of Bordeaux, Pessac, France. Victor de Lédinghen graduated at Bordeaux University, and Cornell University (New York, USA) with a Hepato-Gastroenterology Degree and Medical Degree in 1993, and PhD in 2001. In 2003, he became Professor in Hepatology at the University Hospital of Bordeaux, France. Professor de Lédinghen has a long-standing interest in the non-invasive diagnosis of liver fibrosis and chronic liver diseases, and runs a clinical research programme studying the natural history of liver fibrosis, its impact upon patients and novel therapies for chronic liver diseases associated with liver fibrosis. His hepatology unit is the reference centre for all rare chronic liver diseases (PBC, PSC, Wilson’s disease…) in Nouvelle-Aquitaine (France). He supervises the clinical research programme of new drugs for nonalcoholic steatohepatitis (NASH) and HBV/HDV infection. His research has included participation in national and international HBV, HCV and NAFLD clinical trials, and had led to the publication of more than 300 articles in peer-reviewed journals. He supervises HBV HCV elimination in a large project “Bordeaux Metropolis without viral hepatitis”. He is a member of the European Association for the Study of the Liver, and the American Association for the Study of Liver Diseases. He is former Secretary General of the French Association for the Study of Liver Diseases (AFEF)

Associate Professor Thomas Tu is a molecular biologist and leads a research group at the Westmead Institute for Medical Research in the Storr Liver Centre (Sydney, Australia), where his team focuses on persistent forms of the Hepatitis B virus (covalently closed circular DNA and integrated HBV DNA) and develops methods to measure and eliminate them. He is particularly passionate about developing an HBV cure and mitigating the associated liver cancer, as he himself lives with chronic Hepatitis B. This provides him with unique perspectives on the disease as a researcher, patient, and advocate. He has won multiple awards for his research and outreach, most recently the 2022 Young Tall Poppy Science award. A/Prof Tu is President of the Australian Centre for Hepatitis Virology, the premier Australian society for hepatitis virus researchers. He is also the founder and Director of HepBCommunity.org (a global support network for people affected with HBV), guiding people through their HBV diagnosis, and linking them with trustworthy scientific and medical information. Recently he has established Hepatitis B Voices Australia, an advocacy group run by the affected community.

Date and Time: Tuesday, April 25  12:15 – 13:15

Location: Grand Ballroom 1

ANRS-AFEF Joint Symposium

The French model (8:30 - 10:30)

Moderators:

Fabrice Carrat

Marc Bourlière

France

The French HBV cohort from Hepather and beyond
(8:30 – 9:00)

Marc Bourlière

France

Extra-hepatic events following DAA treatment in patients with chronic hepatitis C: insights from the Hepather cohort linked with ‘Système National des Données de Santé’ medico-administrative data
(9:00 – 9:30)

Fabrice Carrat

HCC findings through the French Cohorts (9:30 – 10:00)

Panel discussion (10:00 – 10:30)

Symposium pré meeting AFEF/ANRS

10:30 - 12:30

Moderators:

Session CHC

Restitution recommandations AFEF cholangioK
(10:30 – 11:00)

Cindy Neuzillet

France

Cohorte française CHIEF : premiers résultats (11:00 – 11:20)

Eric Nguyen Khac

France

L’immunothérapie dans le CHC en 2023 et après (11:20 – 11:50)

Thomas Decaens

France

Session Hépatites virales

VHD : Résultats cohorte ANRS Buledelta (11:50 – 12:10)

Reflex testing VHB-VHD (12:10 – 12:30)

Véronique Loustaud Ratti

France

PLENARY 4

Global Hepatitis Summit 2023 Debrief (11:00 - 13:00)

Moderators:

HCV Debrief (11:00 – 11:25) + Q&A (11:25 – 11:30)

HBV/HDV Debrief (11:30 – 11:55) + Q&A (11:55 – 12:00)

NAFLD/NASH Debrief (12:00 – 12:25) + Q&A (12:25 – 12:30)

HCC Debrief (12:30 – 12:55) + Q&A (12:55 – 13:00)

Massimo Levrero

INSERM U1052 France

Clinical 6

Long-term outcomes of treated patients with viral hepatitis (8:30 - 10:05)

Moderators:

Long-term outcomes of treated HBV patients (8:30 – 8:50) + Q&A (8:50 – 8:55)

Long-term outcomes of cured HCV patients (8:55 – 9:15) + Q&A (9:15 – 9:20)

Effect Of Anti-Cd38 Monoclonal Antibodies On Hepatitis C Virus Replication In Chronically Infected Patients With Multiple Myeloma: A Prospective Series (9:20 – 9:30) + Q&A (9:30 – 9:35)

Harrys A. Torres

Evaluating Differences In On-Treatment Risk Of Hepatocellular Carcinoma Among A Large Cohort Of Predominantly Non-Asian Patients With Non-Cirrhotic Chronic Hepatitis B Infection (9:35 – 9:45) + Q&A (9:45 – 9:50)

Robert Wong

Long Term Follow Up Outcome Of Children Treated With Pegylated Interferon For Hbeag Reactive Chronic Hepatitis B (9:50 – 10:00) + Q&A (10:00 – 10:05)

Bikrant Biharilal Raghuvanshi

Clinical 5

New HDV therapies (8:30 - 10:35)

Moderators:

Maurizia Brunetto

Italy

Raymundo Parana

Brazil

Bulevirtide in HDV therapy (8:30 – 8:50) + Q&A (8:50 – 8:55)

Heiner Wedemeyer

Hannover Medical School Germany

New treatments in HDV (except bulevirtide) (8:55 – 9:15) + Q&A (9:15 – 9:20)

Pietro Lampertico

Italy

Bulevirtide Treatment For Hepatitis D In Decompensated Liver Disease – Clinical Experience Based On Real-World Case Reports (9:20 – 9:30) + Q&A (9:30 – 9:35)

Christopher Dietz-Fricke

Rescue Of Cirrhotic Chronic Hbv / Hdv Infection From Bulevirtide Failure By Subcutaneous Rep 2139-Mg (9:35 – 9:45) + Q&A (9:45 – 9:50)

Marc Bourlière

France

Safety And Efficacy Of Rep 2139-Mg In Association With Tdf In Patients With Chronic Hepatitis Delta And Decompensated Cirrhosis (9:50 – 10:00) + Q&A (10:00 – 10:05)

Christiane Stern

Late-breaker abstract: No Resistance Detected To Bulevirtide Monotherapy In Participants With Chronic Hepatitis D Through 24 Weeks Of Treatment From Phase Ii And Phase Iii Clinical Trials
(10:05 – 10:15) + Q&A (10:15 – 10:20)

Julius Hollnberger

Late-breaker abstract: Extended Follow-Up In The Rep 301 And Rep 401 Studies Demonstrates Durable Clinical Benefit From Nap Therapy
(10:20 – 10:30) + Q&A (10:30 – 10:35)

Andrew Vaillant

Public Health 5

Reaching vulnerable populations for viral hepatitis elimination (8:30 - 10:50)

Moderators:

Manal Al-Sayed

Egypt

Reaching PWID/prison populations for viral hepatitis elimination (8:30 – 8:50) + Q&A (8:50 – 8:55)

Reaching migrant populations for viral hepatitis elimination (8:55 – 9:15) + Q&A (9:15 – 9:20)

Impact Of Hcv Testing And Treatment Services On Hcv Transmission Among Men Who Have Sex With Men And Who Inject Drugs In San Francisco: A Modelling Analysis
(9:20 – 9:30) + Q&A (9:30 – 9:35)

Adelina Artenie

Engagement In Hepatitis C Screening And Treatment Among Pregnant And Postpartum Individuals In Ontario, Canada: A Population-Based Retrospective Cohort Study (9:35 – 9:45) + Q&A (9:45 – 9:50)

Andrew Bryan Mendlowitz

A Community-Based Intervention To Reduce Missed Opportunities In Primary Care For Viral Hepatitis Screening Among At-Risk African Migrants In Catalonia, Spain (9:50 – 10:00) + Q&A (10:00 – 10:05)

Camila A Picchio

Characterizing Operational Models Of Hepatitis B And C Care For Refugee Populations: Results Of A Systematic Review (10:05 – 10:15) + Q&A (10:15 – 10:20)

Ankeeta Saseetharran

Putting People At The Centre: Protocol For Patient Journey Mapping Of Viral Hepatitis Services In Viet Nam And The Philippines (10:20 – 10:30) + Q&A (10:30 – 10:35)

Bethany Holt

The Time Interval From Diagnosis Of Chronic Hepatitis B To Initiation Of Antiviral Therapy And Its Association With Adherence To Treatment In The Gambia (10:35 – 10:45) + Q&A (10:45 – 10:50)

Zakary Warsop

Clinical 8

Impacts of COVID-19 on liver disease management (16:30 - 18:35)

Moderators:

Negative impacts of COVID-19 on liver disease management (16:30 – 16:50) + Q&A (16:50 – 16:55)

Geoffrey Dusheiko

UK

Positive impacts of COVID-19 on liver disease management (16:55 – 17:15) + Q&A (17:15 – 17:20)

Clinical Characteristics Of Patients With Sars-Cov-2 Infection And Pre-Existing Chronic Liver Disease (17:20 – 17:30) + Q&A (17:30 – 17:35)

Sahar Hamza

Impact Of Telemedicine Access To Hepatitis C Specialty Care On The Cascade Of Care: A Retrospective Cohort Study (17:35 – 17:45) + Q&A (17:45 – 17:50)

Jui-Hsia Cleo Hung

Hcv Micro-Elimination In Msm In Germany: Impact Of Directly Acting-Antivirals And Behavior Change Due To The Covid 19 Pandemic (17:50 – 18:00) + Q&A (18:00 – 18:05)

Patrick Ingiliz

Trend Of Timely Hepatitis B Birth Dose Vaccine Coverage In The Gambia And Impact Of The Covid-19 Pandemic (18:05 – 18:15) + Q&A (18:15 – 18:20)

Gibril Ndow

Infant Hepatitis B Vaccination In Africa: Urgent Need To Support Infant Hepatitis B Vaccination Including Birth Dose Vaccine In Africa (18:20 – 18:30) + Q&A (18:30 – 18:35)

Neil Gupta

Clinical 10

Viral hepatitis and liver transplantation in 2023 (16:30 - 17:50)

Moderators:

Sabela Lens

Spain

HCV and liver transplantation: 2023 update (16:30 – 16:50) + Q&A (16:50 – 16:55)

HBV/HDV and liver transplantation: 2023 update (16:55 – 17:15) + Q&A (17:15 – 17:20)

Treatment Of Patients With Hepatitis C After Liver Transplantation: Eight Years Of Real-Life Experience From The Centre Hospitalier De L’universite De Montreal (17:20 – 17:30) + Q&A (17:30 – 17:35)

Isaac Ruiz

Implementation Of The ‘Toronto Protocol’ Glecaprevir/Pibrentasvir+Ezetimibe, For Solid Organ Transplantation From Hcv Nat+ Donors To Hcv-Uninfected Recipients: Moving From Research To Standard Of Care (17:35 – 17:45) + Q&A (17:45 – 17:50)

Basic 8

HEV virology and persistence (16:30 - 18:50)

Moderators:

Ralf Bartenschlager

Germany

Heiner Wedemeyer

Hannover Medical School Germany

Update on HEV virology (16:30 – 16:50) + Q&A (16:50 – 16:55)

Mechanisms of HEV persistance in immunodepressed patients (16:55 – 17:15) + Q&A (17:15 – 17:20)

The Phosphatidylserine Receptor T-Cell Immunoglobulin Mucin Receptor 1 (Tim1) Mediates The Infection Of Enveloped Hepatitis E Virus (17:20 – 17:30) + Q&A (17:30 – 17:35)

Laura Corneillie

The Hepatitis E Virus Infectious Cycle – An Update (17:35 – 17:45) + Q&A (17:45 – 17:50) 

Zongdi Feng

Characterisation Of A Cell Culture System Of Persistent Hepatitis E Virus Infection In The Human Heparg Hepatic Cell Line (17:50 – 18:00) + Q&A (18:00 – 18:05)

Virginie Doceul

Oxysterol Binding Protein (Osbp) Is Needed For Hepatitis E Virus Replication In Cultured Hcellsepatoma Cells (18:05 – 18:15) + Q&A (18:15 – 18:20)

Yanjin Zhang

A Novel Class Of Glycan-Sensitive Human Monoclonal Antibodies Neutralising The Hepatitis E Virus (Hev) (18:20 – 18:30) + Q&A (18:30 – 18:35)

Katja Dinkelborg

Limited Impact On The Functions Of Nf-Κb Essential Modulator (Nemo) In Hepatitis A Virus-Infected Hepatocytes (18:35 – 18:45) + Q&A (18:45 – 18:50)

Hao-En Huang

NoHep Medical Visionaries Symposium

(16:30 - 18:30)

Moderators:

Olufunmilayo Lesi

Nigeria

Su Wang

USA

Lessons learned from HCV medication access and how to prepare for HBV cure (16:30 – 16:45) + Q&A (16:45 – 16:50)

Charles Gore

Challenges and solutions in Africa: Role of decentralization and community based care (16:50 – 17:05) + Q&A (17:05 – 17:10)

Endemic country leadership, a key component of HCV elimination efforts (17:10 – 17:25) + Q&A (17:25 – 17:30)

Isabela Ribeiro

Drugs for Neglected Diseases initiative - DNDi Switzerland

Long term injectable therapies for HBV/HCV (17:30 – 17:45) + Q&A (17:45 – 17:50)

Stigma in HBV/HCV as real barriers to care (17:50 – 18:05) + Q&A (18:05 – 18:10)

Discussion (18:10 – 18:30)

Debate 2

Clinical (14:00 - 16:00)

Chairs:

Maria Buti

Spain

Heiner Wedemeyer

Hannover Medical School Germany

Revisiting HBV treatment guidelines: a 2023 update (14:00 – 14:30)

Understanding HBV biomarkers, redifining new treatment endpoints (14:30 – 15:00)

The path forward in NAFLD/NASH therapeutic developments (15:00 – 15:30)

Vlad Ratziu

France

Classification of HCC patients for therapy (15:30 – 16:00)

Massimo Levrero

INSERM U1052 France

Public Health 3

Viral hepatitis elimination achievements and challenges (14:00 - 16:20)

Moderators:

Mojca Maticic

Slovenia

Global viral hepatitis elimination achievements (14:00 – 14:20) + Q&A (14:20 – 14:25)

Global viral hepatitis elimination challenges (14:25 – 14:45) + Q&A (14:45 – 14:50) 

Gregory Dore

Australia

Eliminating Hepatitis C In Australia: Success Through Workforce And Health Service Delivery Innovation (14:50 – 15:00) + Q&A (15:00 – 15:05)

Joseph Doyle

Achieving Micro-Elimination Of Hepatitis C Hyperendemic Aboriginal Townships In Taiwan: A Successful Model (15:05 – 15:15) + Q&A (15:15 – 15:20)

Chia-Yen Dai

The Community Pop-Up Clinic (Cpc): A Unique Strategy To Engage The Inner City In Hcv Elimination – And More (15:20 – 15:30) + Q&A (15:30 – 15:35)

Brian Conway

Gilead Liver Commitment And Local Elimination Programs Leading To Global Action In Hcv(Lega-C) : The Outcome And Impact From Late Phase Studies (15:35 – 15:45) + Q&A (15:45 – 15:50)

Kyung Min Kwon

Eliminating Hepatitis B: Anticipating Community And Public Health Implications For Any Hepatitis B Curative Interventions (15:50 – 16:00) + Q&A (16:00 – 16:05)

Jack Wallace

Unequal Access To Hbv Diagnostics In Resource Limited Settings Can Hinder Progress Towards The Who 2030 Viral Hepatitis Elimination Targets: International Coalition To Eliminate Hepatitis B Virus (Ice-Hbv) Survey Results (16:05 – 16:15) + Q&A (16:15 – 16:20)

Camila A Picchio

Basic 3

HBV/HDV virology (14:00 - 16:05)

Moderators:

Update on HBV virology (14:00 – 14:20) + Q&A (14:20 – 14:25)

Update on HDV virology (14:25 – 14:45) + Q&A (14:45 – 14:50)

Rxr-Mediated Regulation Of Surface Ntcp Expression And Its Effect On Ntcp-Medated Hepatitis B And Hepatitis D Virus Entry (14:50 – 15:00) + Q&A (15:00 – 15:05)

Hussein H. Aly

Hira Supports Hepatitis B Virus Minichromosome Establishment And Transcriptional Activity In Infected Hepatocytes (15:05 – 15:15) + Q&A (15:15 – 15:20)

Identification And Characterization Of Janus Kinase Jak1 As An Hdv-Related Host Factor And Antiviral Target (15:20 – 15:30) + Q&A (15:30 – 15:35)

Margaux Julie Heuschkel

Single Cell Resolved Analysis Of The Innate Immune Response Of Hdv Infected Stem Cell Derived Hepatocytes (15:35 – 15:45) + Q&A (15:45 – 15:50)

Arnaud Carpentier

Late-breaker abstract: Towards The Structural Characterization Of The Hepatitis Delta Virus Ribonucleoprotein Complex By Nmr
(15:50 – 16:00) + Q&A (16:00 – 16:05)

Yang Yang

Clinical 9

Hepatocellular carcinoma new drug clinical trial (14:15 - 15:05)

Moderators:

Nobuyuki Enomoto

Japan

Jean-Charles Nault

Avicenne Hospital, APHP France

HCC new drug clinical trials in Europe and North America (14:15 – 14:35) + Q&A (14:35 – 14:40)

HCC new drug clinical trials in Asia (14:40 – 15:00) + Q&A (15:00 – 15:05)

PLENARY 3

New vaccine approaches for liver diseases (11:00 - 13:00)

Moderators:

Michael Manns

Germany

Lessons from SARS-CoV-2 vaccination and boosting in non-human primates (11:00 – 11:25) + Q&A (11:25 – 11:30) 

Towards an HCV vaccine (11:30 – 11:55) + Q&A (11:55 – 12:00)

The future of therapeutic vaccines for viral infections (12:00 – 12:25) + Q&A (12:25 – 12:30)

Implementing global vaccination strategies (12:30 – 12:55) + Q&A (12:55 – 13:00)

Basic 9

Liver inflammation and fibrogenesis (8:30 - 9:50)

Moderators:

François Dufour

Switzerland

Mathias Heikenwalder

Germany

Mechanisms of NAFLD/NASH-associated liver inflammation (8:30 – 8:50) + Q&A (8:50 – 8:55) 

Mechanisms of liver fibrogenesis (8:55 – 9:15) + Q&A (9:15 – 9:20)

Fabio Marra

Italy

Gene Expression Analysis Of Diseased And Control Liver Tissue To Explore Pathogenic Pathways In Inflammation (9:20 – 9:30) + Q&A (9:30 – 9:35)

Michael Stephanou

Auto-Aggressive Cd8 T Cells Represent Common Effectors Of Liver Damage Across Stages Of Chronic Hepatitis B (9:35 – 9:45) + Q&A (9:45 – 9:50)

Clinical 4

New HBV drug clinical developments (8:00 - 10:20)

Moderators:

Marc Bourlière

France

Direct-acting antiviral HBV drugs in development (8:00 – 8:20) + Q&A (8:20 – 8:25)

Anti-HBV immunotherapies and combination perspectives (8:25 – 8:45) + Q&A (8:45 – 8:50)

Late-breaker abstract: Mechanistic Pk/Pd Modeling And Simulation Of Bepirovirsen Pk, Hbsag And Alt Changes From Phase 2b Study To Inform Phase 3 Study Design And Dose Selection: B-Clear Study (8:50 – 9:00) + Q&A (9:00 – 9:05)

Nadia Noormohamed

Late-breaker abstract: Pharmacokinetics And Safety Of Single-Dose Bepirovirsen In Adults With Moderate Hepatic Impairment And Healthy Matched Controls (B-Assured) (9:05 – 9:15) + Q&A (9:15 – 9:20)

Nadia Noormohamed

Late-breaker abstract: 48 Weeks Of Ab-729 + Nucleos(T)Ide Analogue (Na) Therapy Results In Profound, Sustained Hbsag Declines In Both Hbeag+ And Hbeag- Subjects Which Are Maintained In Hbeag- Subjects Who Have Discontinued All Therapy (9:20 – 9:30) + Q&A (9:30 – 9:35)

Late-breaker abstract: Treatment for >12 Weeks with the Capsid Assembly Modulator (CAM) ALG-000184 and Entecavir (ETV) Dose Dependently Reduces HBsAg in HBeAg+ Subjects with Chronic Hepatitis B (CHB) (9:35 – 9:45) + Q&A (9:45 – 9:50)

Late-breaker abstract: 3-Antigen Hbv Vaccine, With Pre-S1, Pre-S2 And S Antigens, Induces A Higher And More Durable Immune Response Compared To 1-Antigen Hbv Vaccine (9:50 – 10:00) + Q&A (10:00 – 10:05)

Lutz Maubach

Late-breaker abstract: Under-Representation Of Who Africa Region In Hbv Clinical Trials: The Field Advances, But In Which Direction? (10:05 – 10:15) + Q&A (10:15 – 10:20)

Marion Delphin

Basic 7

HCC targets for new therapies (8:30 - 10:05)

Moderators:

Chiara Raggi

Italy

Molecular targets for HCC therapy
(8:30 – 8:50) + Q&A (8:50 – 8:55)

Immunological targets for HCC therapy (8:55 – 9:15) + Q&A (9:15 – 9:20) 

Expression Of The Axonal Guidance Cue Netrin-1 Associates With Neoneurogenesis Of Druggable Cholinergic Orientation And Aggressive Hcc Features (9:20 – 9:30) + Q&A (9:30 – 9:35)

Charlotte A. Hernandez

Enhancer Of Zeste Homolog 2 (Ezh2) And O-Glcnac Transferase (Ogt) Modulate Cell Cycle And Cancer-Associated Pathways In Hepatocellular Carcinoma (9:35 – 9:45) + Q&A (9:45 – 9:50)

Margot Thirion

Targeting Cd63 As A Novel Fibrogenic Immune Target For The Treatment Of Hepatocellular Carcinoma And The Reversion Of Hepatic Fibrosis (9:50 – 10:00) + Q&A (10:00 – 10:05)

Cristabelle De Souza

Gerlinde Wernig

Clinical 7

NAFLD/NASH therapeutic developments (16:30 - 17:50)

Moderators:

Clinical Trial dndpoints in NASH cirrhosis (16:30 – 16:50) + Q&A (16:50 – 16:55)

New treatment approaches for NAFLD/NASH (16:55 – 17:15) + Q&A (17:15 – 17:20)

Obesity Is Associated With A Late-Stage Hepatocellular Carcinoma At Diagnosis Despite Adequate Ultrasound Surveillance (17:20 – 17:30) + Q&A (17:30 – 17:35)

Hooman Farhang Zangneh

Efficacy And Safety Of Alxn1840 Versus Standard Of Care In Wilson Disease: Primary Results From An Ongoing Phase 3, Randomized, Controlled, Rater-Blinded Trial (17:35 – 17:45) + Q&A (17:45 – 17:50)

Aftab Ala

Public Health 2

Global epidemiology of HBV/HDV infections (16:30 - 18:35)

Moderators:

Olufunmilayo Lesi

Nigeria

Global epidemiology of HBV infection (16:30 – 16:50) + Q&A (16:50 – 16:55)

Global epidemiology of HDV infection (16:55 – 17:15) + Q&A (17:15 – 17:20)


The Burden Of Hepatitis B Virus (Hbv) Infection In Children And Women Of Reproductive Age In Nigeria, 2018 (17:20 – 17:30) + Q&A (17:30 – 17:35)

Annemarie Wasley

Clinical Characteristics And Outcomes Of Patients With Cirrhosis And Hepatocellular Carcinoma In The Gambia, West Africa (17:35 – 17:45) + Q&A (17:45 – 17:50)

Gibril Ndow

Updated Prevalence Of Chronic Hepatitis B And Hepatitis Delta Infection Among Foreign-Born Individuals In The United States In 2021 (17:50 – 18:00) + Q&A (18:00 – 18:05)

Robert Wong

National Prevalence And Risk Factors Of Hepatitis Delta Virus Infection In Hbsag Positive Subjects In Cameroon, Central Africa (18:05 – 18:15) + Q&A (18:15 – 18:20)

Richard Njouom

High Molecular Diversity And Remarkable Geographical Distribution Of Hepatitis Delta Virus Strains, That Are Spreading In Cameroon (18:20 – 18:30) + Q&A (18:30 – 18:35)

Segolene Brichler

Basic 2 + 4

Hepatitis immunology (16:30 - 18:40)

Moderators:

Markus Heim

Switzerland

Matteo Ianacone

Italy

Hélène Strick-Marchand

France

Immunological phenotyping of HBV infections (16:30 – 16:50) + Q&A (16:50 – 16:55)

Liver compartmentalization of anti-HBV immune responses (16:55 – 17:15) + Q&A (17:15 – 17:20)

The Development Of A Pan-Genotypic Prophylactic Viral Vectored T Cell Vaccine Against Hepatitis C Virus (17:20 – 17:30) + Q&A (17:30 – 17:35)

Rebecca India Strain

Innate immune responses against HBV and HCV (17:35 – 17:55) + Q&A (17:55 – 18:00)

Adaptive immune responses against HCV (18:00 – 18:20) + Q&A (18:20 – 18:25)

Maike Hofmann

University Medical Center Freiburg Germany

Ex Vivo Immunological Assays Have The Potential To Predict Response To Pd-1 Targeting Therapies In Chronic Hepatitis B Patients (18:25 – 18:35) + Q&A (18:35 – 18:40)

Clinical 12

New developments in liver pathogen detection and discovery (16:30 - 18:20)

Moderators:

Gaston Picchio

USA

Metagenomics for pathogen diagnosis and discovery (16:30 – 16:50) + Q&A (16:50 – 16:55)

Acute severe hepatitis of unknown origin in children (16:55 – 17:15) + Q&A (17:15 – 17:20)

A Novel Technology For Diagnosis Of Hcv Viremia Using Thermo-Sensitive Smart Polymer: Pilot Study Of A Point Of Care Test Of Hcv Compared To Polymerase Chain Reaction Test (Pcr) (17:20 – 17:30) + Q&A (17:30 – 17:35)

Riham Soliman

Innovative Approach Using Clinical Metagenomics For The Diagnosis Of Non-Elucidated Liver Diseases (17:35 – 17:45) + Q&A (17:45 – 17:50)

Anna Sessa

Acute Hepatitis Of Unknown Etiology (Ahua) In Israeli
Children: Human Herpesvirus 6 (Hhv6) As A Possible Trigger For The Disease (17:50 – 18:00) + Q&A (18:00 – 18:05)

Yael Gozlan

Severe Acute Hepatitis Of Unknown Etiology Presenting As Acute Liver Failure In Children: Outcomes From The Liver Intensive Care Unit (18:05 – 18:15) + Q&A (18:15 – 18:20)

Bikrant Biharilal Raghuvanshi

Debate 1

Public Health (14:00 - 16:00)

Chairs:

Niklas Luhmann

Switzerland

Post-COVID relaunch of HCV testing/treatment (14:00 – 14:30)

Improving screening and linkage-to-care in viral hepatitis B and C (14:30 – 15:00)

Public health interventions and awareness in NAFLD/NASH
(15:00 – 15:30)

Cyrielle Caussy

France

Engaging policy makers and patient advocacy groups in liver disease (15:30 – 16:00)

Marko Korenjak

Slovenia

Clinical 2

Difficult-to-treat HCV patients (14:00 - 16:00)

Moderators:

Geoffrey Dusheiko

UK

Jia-Horng Kao

National Taiwan University Hospital Taiwan

Unusual HCV genotypes/subtypes (14:00 – 14:20) + Q&A (14:20 – 14:25)

Difficult-to-cure HCV liver diseases (14:25 – 14:45) + Q&A (14:45 – 14:50)

Glecaprevir/Pibrentasvir Is Safe And Effective In Italian Patients With Chronic Hepatitis C Aged 75 Years Or Older: A Multicenter Study (14:50 – 15:00) + Q&A (15:00 – 15:05)

Nicola Pugliese

Introducing Affordable, Generic Second-Line Treatment For Hepatitis C Elimination In Rwanda: Preliminary Results (15:05 – 15:15) + Q&A (15:15 – 15:20)

Peter Barebwanuwe

Janvier Serumondo

Efficacity Of Two Last-Generation Daa In Infrequent Hepatitis C Genotypes/Subtypes: Real-World Data From The Centre Hospitalier De L’universite De Montreal (15:20 – 15:30) + Q&A (15:30 – 15:35)

Isaac Ruiz

Real-Life Study Of Resistance-Associated Substitutions To Ns5a And Ns5b Inhibitors In Hcv Infected Patients From Argentina (15:35 – 15:45) + Q&A (15:45 – 15:50)

Maria Laura Minassian

EASL-AASLD Joint Symposium 2

Disparities in Liver Cancer (14:00 - 16:00)

Moderators:

AASLD

EASL

Jean-Charles Nault

Avicenne Hospital, APHP France

PART I

Introductions
(14:00 – 14:05)

Disparities in implementation of screening guidelines (14:05 – 14:25) 

EASL

Manon Allaire

Pitié Salpetrière Hospital France

Disparities and treatment outcomes (14:25 – 14:45)

AASLD

Michael E. DeBakey

VA Medical Center USA

Q&A / Joint Panel EASL & AASLD (14:45 – 15:05)

PART II

HCV Screening in underserved cohorts at high risk for HCC (15:05 – 15:25)

AASLD

Impact of social determinants of health on HCC outcomes (15:25 – 15:45)

EASL

Q&A / Joint Panel AASLD & EASL (15:45 – 16:00)

Basic 6

NASH targets for new therapies (14:15 - 15:50)

Moderators:

Mathias Heikenwalder

Germany

Cyrielle Caussy

France

Molecular targets for NASH therapy
(14:15 – 14:35) + Q&A (14:35 – 14:40)

Mathias Heikenwalder

Germany

Preclinical assessment of NASH compounds (14:40 – 15:00) + Q&A (15:00 – 15:05)

Arun Sanyal

Virginia Commonwealth University United States

Dyrk1b Induces Fatty Liver Disease And Its Disruption Is Protective Against Liver Steatohepatitis And Liver Fibrosis (15:05 – 15:15) + Q&A (15:15 – 15:20)

Arya Mani

The Ccaat/Enhancer-Binding Protein Beta – Serpinb3 Axis Inhibition As A Novel Strategy For Non-Alcoholic Steatohepatitis Treatment (15:20 – 15:30) + Q&A (15:30 – 15:35)

Andrea Martini

Late-breaker abstract: Bone Marrow Monocytes Sustain Nk Cell Development And Survival During Non-Alcoholic Steatohepatitis (Nash) (15:35 – 15:45) + Q&A (15:45 – 15:50)

Elsa Bourayou

PLENARY 2

Public health interventions in liver diseases (11:00 - 13:00)

Moderators:

Public health tools to eliminate viral hepatitis (11:00 – 11:25) + Q&A (11:25 – 11:30)

Global achievements and failures in viral hepatitis elimination (11:30 – 11:55) + Q&A (11:55 – 12:00)

Meg Doherty

WHO Switzerland

HCV elimination in Egypt: a success story (12:00 – 12:25) + Q&A (12:25 – 12:30)

Public health interventions to eliminate NAFLD/NASH (12:30 – 12:55) + Q&A (12:55 – 13:00)

Public Health 4

Simplified approaches for screening and diagnosis of viral hepatitis (8:30 - 10:50)

Moderators:

Imam Waked

Egypt

Simplified approaches for HCV screening and diagnosis (8:30 – 8:50) + Q&A (8:50 – 8:55)

Simplified approaches for HBV/HDV screening and diagnosis (8:55 – 9:15) + Q&A (9:15 – 9:20)

Dried Blood Spot (Dbs): A New Tool For Screening, Diagnosis And Monitoring Hepatitis D Virus (Hdv) Infection (9:20 – 9:30) + Q&A (9:30 – 9:35)

Rola Matar

Treatment Eligibilty And Performance Of The Who Treatment Criteria In Chronic Hepatitis B Patients In Tanzania (9:35 – 9:45) + Q&A (9:45 – 9:50)

Naveeda Adam

A National Program To Scale-Up Decentralized Hepatitis C Virus Point-Of-Care Testing And Treatment In Australia (9:50 – 10:00) + Q&A (10:00 – 10:05)

Effectiveness Of Reflex Hcv Viral Load Sample Collection In Improving Turn-Around Time For Hcv Diagnostics In Nasarawa State Nigeria (10:05 – 10:15) + Q&A (10:15 – 10:20)

Chukwuemeka Agwuocha

Acceptability And Usability Of Oral Fluid Hcv Self-Testing For Hepatitis C Testing: A Systematic Review (10:20 – 10:30) + Q&A (10:30 – 10:35)

Samara Luiza Silva

Combined Covid-19 Vaccination And Hepatitis C Virus Screening Intervention In Marginalised Populations In Spain (10:35 – 10:45) + Q&A (10:45 – 10:50)

Clinical 11

New biomarkers for liver diseases (8:30 - 10:35)

Moderators:

Alina Allen

USA

Jérôme Boursier

France

New biomarkers for fibrosis assessment (8:30 – 8:50) + Q&A (8:50 – 8:55)

New biomarkers for HCC risk prediction (8:55 – 9:15) + Q&A (9:15 – 9:20)

Circulating Hbv Rna Correlates With Intrahepatic Covalently Closed Circular Dna (Cccdna) Transcriptional Activity In Untreated And Nuc-Treated Chronic Hepatitis B (Chb) Patients (9:20 – 9:30) + Q&A (9:30 – 9:35)

Development And Clinical Utility Of High-Throughput Hbcag-Specific Immunoassays For The Management Of Hbv Therapies (9:35 – 9:45) + Q&A (9:45 – 9:50)

Rene Geissler

Hepatitis B Core Related Antigen (Hbcrag), Not As Good As It Seems?: A Critique And Systematic Review (9:50 – 10:00) + Q&A (10:00 – 10:05)

The Use Of Limax In Predicting Clinically Relevant Milestones In Chronic Liver Disease Of Different Aetiologies (10:05 – 10:15) + Q&A (10:15 – 10:20)

Anushri Joshi

Late-breaker abstract: Circulating Fibroblast Activation Protein Alpha (Fap) And Dipeptidyl Peptidase 4 (Dpp4) As Biomarkers For Fibrosis And Steatosis
(10:20 – 10:30) + Q&A (10:30 – 10:35)

Mark D Gorrell

EASL-AASLD Joint Symposium 1

The Impact of social media in Liver Disease Research and Education – Is it time to embrace this more widely? (8:30 - 10:30)

Moderators:

What do I gain from my involvement in social media – the viewpoint of a senior academic (8:30 – 8:50)

AASLD

Medical Education Opportunities in social media – Tweetorials, journal clubs and more (8:50 – 9:10)

AASLD

An Editor’s View on the role of social media in the dissemination of research findings (9:10 – 9:30)

EASL

Jean-Charles Nault

Avicenne Hospital, APHP France

Medical social media and the ‘Echo Chamber’ – the good, the bad and the ugly (9:30 – 9:50)

EASL

Walter Quattrociocchi

Italy

Debate: HCPs have a moral obligation to be involved in social media to counteract disinformation (9:50 – 10:05)

Panel Discussion (10:05 – 10:20)

Basic 5

HBV/HDV treatment targets (8:30 - 10:35)

Moderators:

Lena Allweiss

Germany

David Durantel

France

Targeting HBV capsids for therapy (8:30 – 8:50) + Q&A (8:50 – 8:55)

Targeting HBV RNAs for therapy (8:55 – 9:15) + Q&A (9:15 – 9:20)

Class A Capsid Assembly Modulators Induce Cell Death Through Hbv Core Protein Aggregation And Potentially Activate The Innate Immune Response (9:20 – 9:30) + Q&A (9:30 – 9:35)

Valerio Taverniti

A Gene Editing Approach For Chronic Hepatitis B: Elimination Of Hepatitis B Virus In Vivo By Targeting Cccdna And Integrated Viral Genomes With A Sequence-Specific Arcus Nuclease (9:35 – 9:45) + Q&A (9:45 – 9:50)

Cassandra Gorsuch

The Tlr8 Agonist Selgantolimod Modulates Kupffer Cell Differentiation Status And Indirectly Impairs Hbv Entry Into Hepatocytes Via An Il-6-Dependent Mechanism (9:50 – 10:00) + Q&A (10:00 – 10:05)

Armando Andres Roca Suarez

Therapeutic Vaccination For Chronic Hepatitis B Using Adjuvant-Loaded Particulate Hepatitis B Core Antigen (10:05 – 10:15) + Q&A (10:15 – 10:20)

Jinpeng Su

Fxr Agonists Alone Or In Combination With Ifna Inhibit Hbv Replication And Hdv Propagation In Functional Hepatocytes (10:20 – 10:30) + Q&A (10:30 – 10:35)

Romain Barnault

Clinical 3

New strategies with approved HBV treatments (16:30 - 18:35)

Moderators:

Xin-Xin Zhang

China

Stoppings NUC strategies (16:30 – 16:50) + Q&A (16:50 – 16:55)

Interferon add-on/switch strategies (16:55 – 17:15) + Q&A (17:15 – 17:20)

Switching Tenofovir Disoproxil Fumarate (Tdf) To Tenofovir Alafenamide Fumarate (Taf) In Hepatitis B/Hiv Co-Infection: A Feasibility Study (17:20 – 17:30) + Q&A (17:30 – 17:35)

James Lok

Tenofovir Disoproxil Fumarate (Tdf) Versus Tenofovir Alafenamide (Taf) Or Tdf/Emtricitabine (Tdf/Ftc) To Treat Hepatitis B: Meta-Analysis Of 2914 Patients In 11 Randomised Clinical Trials (17:35 – 17:45) + Q&A (17:45 – 17:50)

Andrew Hill

Hepatitis B Surface Antigen Kinetics During And After Nucleos(T)Ide Analogues Described By Mathematical Modeling (17:50 – 18:00) + Q&A (18:00 – 18:05)

Piero Colombatto

Early Off-Treatment Kinetics Of Viral And Host Biomarkers After Discontinuation Of Nucleos(T)Ide Analogues Among Chronic Hepatitis B Patients (Retract-B Study) (18:05 – 18:15) + Q&A (18:15 – 18:20)

Grishma Hirode

The Long-Term Prognosis And The Need For Histologic Assessment In Chronic Hepatitis B In Serological Immune-Tolerant Phase (18:20 – 18:30) + Q&A (18:30 – 18:35)

Jeong-Ju Yoo

Clinical 1

Applications of artificial intelligence in liver disease management (16:30 - 17:50)

Moderators:

Valérie Paradis

France

Pascal Roy

France

Data sciences in viral hepatitis (16:30 – 16:50) + Q&A (16:50 – 16:55)

Artificial intelligence for liver cancer management (16:55 – 17:15) + Q&A (17:15 – 17:20)

Prediction Of Hbv-Related Cirrhosis Complications With Machine Learning Algorithms Using Electronic Health Records (17:20 – 17:30) + Q&A (17:30 – 17:35)

Vivian Chia-Rong Hsieh

Spatial Transcriptomics Reveals Widespread Intrahepatic Hepatitis B Virus Integration In Chronic Infected Patients (17:35 – 17:45) + Q&A (17:45 – 17:50)

Xiaoqi Yu

Public Health 1

Epidemiology of HCV in resource-limited countries (16:30 - 18:20)

Moderators:

Tarik Asselah

France

Erika Duffell

Sweden

Prevalence of HCV infection in resource-limited countries (16:30 – 16:50) + Q&A (16:50 – 16:55)

Dynamics of the HCV epidemic in resource-limited countries (16:55 – 17:15) + Q&A (17:15 – 17:20)

High Hcv Incidence Is Associated With Social And Spatial Network Structures Among People Who Inject Drugs In New Delhi (17:20 – 17:30) + Q&A (17:30 – 17:35)

Steven J. Clipman

An Unexpectedly High Hepatitis C Virus Prevalence In Southern Laos Led To The Identification Of Risk Practices And Suggested That Extensive Testing And Treatment Are Required (17:35 – 17:45) + Q&A (17:45 – 17:50)

Judith M Hübschen

Rising Trend Of Symptomatic Infections Due To Hepatitis A Virus Infection In Adolescent And Adult Age Group: An Observational Study From A Tertiary Care Liver Institute In India (17:50 – 18:00) + Q&A (18:00 – 18:05)

Jasmine Samal

Late-breaker abstract: Understanding Hepatitis C Reinfection Rates And Factors Associated With Hcv Infection In New Jersey, USA (18:05 – 18:15) + Q&A (18:15 – 18:20)

Corey L DeStefano

Jihad Slim

Basic 1

HCV/flavivirus virology (16:30 - 18:35)

Moderators:

Mirjam Zeisel

France

Naglaa Shoukry

Canada

What did HCV teach us on flavivirus virology (16:30 – 16:50) + Q&A (16:50 – 16:55)

HCV entry: lessons learnt for other viruses (16:55 – 17:15) + Q&A (17:15 – 17:20)

A Step-Wise Adaptation Of Hepatitis C Virus Leads To A High Rate Of Infection In Primary Mouse Hepatocytes (17:20 – 17:30) + Q&A (17:30 – 17:35)

Julie Sheldon

Evaluation Of Hepatitis C Virus Transmitted/Founder Variants Obtained From Observed Hcv Infection Through Lung Transplantation From Hcv-Infected Donors To Uninfected Recipients (17:35 – 17:45) + Q&A (17:45 – 17:50)

Nahla Fadlelmawla

Demonstration Of Hcv Rna Methylation In Clinical Isolates And Comparison With Cell Culture-Derived Virus (17:50 – 18:00) + Q&A (18:00 – 18:05)

Nahla Fadlelmawla

Comparison Of Hav And Hcv Infections In Vivo And In Vitro Reveals Distinct Patterns Of Innate Immune Evasion And Activation (18:05 – 18:15) + Q&A (18:15 – 18:20)

Ombretta Colasanti

Virological Characterization Of Treatment Failures And Retreatment Outcomes In Patients Infected With “Unusual” Hcv Genotype 1 Subtypes (18:20 – 18:30) + Q&A (18:30 – 18:35)

Erwan Vo Quang

Late-breaker abstract: Intracellular “In Silico Microscopes” – Fully 3d Spatial Hepatitis C Virus Replication Model Simulations (18:35 – 18:45) + Q&A (18:45 – 18:50)

PLENARY 1

Innovations in liver disease therapy: present and future

Moderators:

Innovations in direct-acting antiviral therapies (14:00 – 14:25) + Q&A (14:25 – 14:30)

Innovations in antiviral immunotherapy (14:30 – 14:55) + Q&A (14:55 – 15:00)

Innovations in liver fibrosis and NASH therapy (15:00 – 15:25) + Q&A (15:25 – 15:30)

Arun Sanyal

Virginia Commonwealth University United States

Innovations in hepatocellular carcinoma therapy (15:30 – 15:55) + Q&A (15:55 – 16:00)

SIGN ME UP FOR UPDATES

Margaret Hellard

Deputy Director Burnet Institute

Professor Margaret Hellard AM is a Deputy Director at the Burnet Institute, Head of Hepatitis Services in Department of Infectious Diseases at The Alfred Hospital and an Adjunct Professor at Monash University and University of Melbourne, Melbourne, Australia. Margaret is an infectious disease physician, public health physician and infectious diseases epidemiologist (and yes was one prior to COVID), with her work focusing on the management of blood borne viruses; the ultimate aim being to eliminate viral hepatitis as a public health threat and end the HIV/AIDS epidemic. A key aspect of this work is to ensure equity of access to all people at risk of blood borne viruses, including people who inject drugs. Since the COVID pandemic, Margaret has continued her blood borne virus work, whilst also undertaking modelling, public health and epidemiology studies aimed at reducing the direct and indirect impacts of the COVID-19 epidemic on the community. Again a focus is ensuring health and social equity for groups at greater risk of COVID infections and the public health responses aimed at reducing COVID. Margaret is a member of numerous advisory committees and working groups on viral hepatitis and HIV within Australia and globally, including Co-Chairing the WHO Strategic and Technical Advisory Group on HIV, Viral Hepatitis and STIs.

Olufunmilayo Lesi

WHO WHO

Currently works at WHO, Geneva , Switzerland and coordinates the Viral hepatitis programmme across the technical areas and implementation of interventions for country impact. She has participated in the development of validation criteria for hepatitis elimination and lead the project on assessing these criteria across 7 countries in the WHO regions. She is also Professor of Medicine and Hepatology with extensive clinical experience in patient care in Africa.

Philippa Easterbrook

Global Hepatitis Programme WHO

Professor Philippa Easterbrook is a senior infectious disease and public health researcher, epidemiogist and physician, who has dedicated more than three decades to clinical care, research, and scale-up of the global response to the HIV epidemic, and the last 7 years also to the global elimination of hepatitis C and B infection. She is currently based in the HIV, Hepatitis and STI department at the World Health Organisation Headquarters in Geneva, where she has led and coordinated the scientific research and evidence-base and development of WHO global normative guidance in HIV and viral hepatitis B and C infection, alongside implementation of testing and treatment scale-up in low and middle-income countries. For eleven years, she was Head of Department, Professor of HIV Medicine, and consultant physician in Infectious Diseases at King´s College London, and also served as Head of Research at the Infectious Diseases Institute, Makerere University, Kampala, Uganda. Her research has encompassed epidemiology, clinical trials, operational/implementation science and laboratory-based studies.

Guadalupe Garcia-Tsao

Yale University / VA-CT Healthcare System Yale University / VA-CT Healthcare System

Dr. Guadalupe Garcia-Tsao is Professor of Medicine at Yale University and at the VA-Connecticut Healthcare System. She is also Director of the Clinical Core of the NIH-funded Yale Liver Center and Associate Editor for the NEJM. Dr. Garcia-Tsao’s investigation focuses on cirrhosis, portal hypertension and related complications, having authored over two hundred original research publications in addition to several society guidelines and position papers in the field. Her H-index is 99.

Anna Lok

Professor University of Michigan

Dr. Lok completed her medical training in Hong Kong and hepatology training with Professor Dame Sheila Sherlock in London. She is Professor and Director of Hepatology and Assistant Dean for Clinical Research at the University of Michigan, Ann Arbor. She has been involved in research on viral hepatitis and hepatocellular carcinoma for 4 decades and co-authored every version of the AASLD Hepatitis B guidelines since its inception in 2001.

John Ward

Director Task Force for Global Health/ Coalition for Global Hepatitis Elimination

Dr Ward directs the Coalition for Global Hepatitis Elimination of the Task Force for Global Health providing a communities of practice for hepatitis elimination programs to collaborate, receive technical assistance, participate in operational research. Dr Ward advises hepatitis elimination activities at WHO and other organizations. Over a 13-year tenure, Dr Ward directed the US CDC Division of Viral Hepatitis. . Dr Ward has authored over 175 scientific publications. Dr Ward is a Professor in the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta.

Pierre Nahon

Professor of Hepatology APHP

Pierre Nahon is Professor of Hepatology at Avicenne Hospital in Bobigny, APHP, France. He is also a clinical scientist at INSERM U1138, studying the constitutional genomics of liver cancer. Professor Nahon gained his medical degree from the University of Paris 13, before undertaking a PhD in biology. Subsequently, he completed a Higher Degree for Research (HDR) at the University of Paris 13. Professor Nahon’s research interests focus on the complications of cirrhosis, in particular hepatocellular carcinoma. He is the Scientific Coordinator of the French National Agency for Research on AIDS and Viral Hepatitis CO12 CirVir cohort, which is a prospective follow-up of nearly 1800 patients with compensated viral cirrhosis and sequential biobanks in 35 centres across France currently under exploration for multiple biomarker studies (RHU DELIVER). He also coordinates a WP dedicated to AI, biomarkers and HCC surveillance in the setting of the GENIAL H2020 European project. Professor Nahon is also the co-Coordinator of a GWAs within the Genetic work package of the French Hepatocellular Carcinoma Multi-technological Project (HECAM) published in the Lancet Oncology. He also obtained funding for the implementation of multicentric Phase 2 trials testing the efficacy of combining percutaneous ablation with neo- and adjuvant immunotherapy or TKI for the treatment of hepatocellular carcinoma (NCT03630640 NIVOLEP and NCT05113186 LENVABLA trials). More recently, he coordinates an academic randomized trial testing abbreviated MRI for the early detection of HCC in high-risk patients with cirrhosis (NCT05095714 FASTRAK trial). He is a member of the editorial board of the Journal of Hepatology and is Associate Editor for Liver International. He is an ad hoc reviewer for numerous other scientific journals including Lancet Gastroenterology and Hepatology, Gastroenterology, Gut, Hepatology, Cancer Research, Annals of Oncology and Carcinogenesis.

Victor de Lédinghen

MD PhD CHU Bordeaux

Head of the expert center for viral hepatitis in Nouvelle-Aquitaine

Charlotte Costentin

Session Co-Moderator (AFEF-ANRS) & Speaker (AASLD-EASL) CHU Grenoble

I graduated from Paris VI University, Medical School, in 2001, earned a Master of Public Health from Harvard University Boston USA in 2018, and a PhD in Epidemiology in 2020. I am currently full Professor of Hepatology at Grenoble Alpes University, France, since septembre 2021. My clinic is dedicated to liver diseases including liver cancer. My research and teaching focus on understanding gaps in health trajectories, from exposure to chronic liver disease risk factors to liver cancer developpement and managment. I developped a particular interest for social determinants of health, including sex/gender, and their impact on disparities in liver cancer outcomes.

Jean-Michel Pawlotsky

Henri Mondor Hospital University of Paris

Dr Jean-Michel Pawlotsky is Professor of Medicine at the University of Paris-Est. He is the Director of the Department of Virology at the Henri Mondor University Hospital in Créteil, France, and Director of research team “Viruses-Hepatology-Cancer“ at the Mondor Institute of Biomedical Research (INSERM U955). He focuses on teaching and research in virology (primarily hepatitis viruses) and liver oncology.

Dr Pawlotsky earned his medical degree in Hepatology and Gastroenterology in 1992. In addition, he earned a Thesis in molecular virology from the University of Paris, France, and he is a graduate in virology from the Pasteur Institute in Paris and microbiology from the University of Paris. Dr Pawlotsky has been acting as the Secretary General of the European Association for the Study of the Liver (EASL) between 2005 and 2009. He is in charge of the Young Investigators program at the National Agency for Research on AIDS and Viral Hepatitis/Emerging Infectious Diseases (ANRS). Dr Pawlotsky has been an Associate Editor of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), between 2001 and 2006, and an Associate Editor of Gastroenterology, the official journal of the American Gastroenterological Association (AGA), between 2011 and 2016.

Dr Pawlotsky’s noted career contributions include the publication of over 650 articles and book chapters in his areas of expertise and over 900 invited lectures at international and national meetings.

Fabien Zoulim

Head of Viral Hepatitis Univerity of Lyon / Lyon Civil Hospital / INSERM

Fabien Zoulim obtained his M.D. in Gastroenterology and Hepatology in Lyon Medical School in 1991. He has also obtained a PhD in Molecular and Cellular Biology and was trained as a post-doctoral researcher at Fox Chase Cancer Center in Philadelphia. He is Professor of Medicine at Lyon I University since 1997. He is Head of the Hepatology Department at the Hospices Civils de Lyon, Head of the Viral Hepatitis Research Laboratory of INSERM Unit 1052, and founded the Lyon Hepatology Institute in 2021. Dr Zoulim served as a Governing Board member of the European Association for the Study of the Liver (EASL) and is currently Associate Editor for Gut. He received the 2022 Distinguished Award in Hepatitis B Research and the 2023 Gertrude Elion Award of the International Society for Antiviral Research. He is coordinating the ANRS “HBV cure” Task Force in France and the “IP-cure-B” project within the EU H2020 workprogram. He co-founded the International Coalition to Eliminate HBV (ICE-HBV: http//:www.ice-hbv.org). Dr Zoulim has published 588 articles (Web of Science H index 89) and is a member of the highly cited researchers (Clarivate 2021).

Norah Terrault

Professor of Medicine University of Southern California

Dr. Norah Terrault is a transplant hepatologist and Professor of Medicine, Neil Kaplowitz endowed Chair of Liver Diseases Research and Chief of Gastroenterology and Liver Diseases at the Keck School of Medicine at University of Southern California. Dr. Terrault has focused her clinical and research activities on viral hepatitis and non-alcoholic fatty liver disease, with specific focus on patients with cirrhosis and liver transplant recipients. In addition to multiple clinical trials related to preventing and treating chronic hepatitis viral hepatitis and fatty liver, Dr. Terrault has been PI on multiple NIH-funded studies, including the current NIH-supported HBV clinical research network (HBRN), nonalcoholic steatohepatitis clinical research network (NASH CRN) and Liver Cirrhosis Network (LCN). She has authored over 400 peer-reviewed manuscripts, editorials, invited reviews as well as US national guidelines for treatment of chronic hepatitis B and C and reproductive health. Dr. Terrault is a Councilor on the AASLD governing board and will serve as president in 2023.

Nancy Reau

Physician Rush University Medical Center

Nancy Reau is currently the chief of hepatology at Rush University Medical Center and co-director of liver transplantation. She completed her training at The Ohio state University of Medicine and her hepatology training at Johns Hopkins University.

Jordan Feld

Head of Hepatology / Toronto Centre for Liver Disease University Health Network

JORDAN J FELD MD MPH Professor of Medicine, University of Toronto, Ontario, Canada Dr. Feld trained in GI and Hepatology at the University of Toronto and did post-doctoral training in the Liver Diseases Branch at the National Institutes of Health in laboratory and clinical research in viral hepatitis. After completing a Masters in Public Health at the Johns Hopkins Bloomberg School of Public Health, he returned to Toronto. He is a Professor of Medicine at the University of Toronto and holds the R. Phelan Chair in Translational Liver Research as a clinician-scientist at the Toronto Centre for Liver Disease in the Toronto General Hospital where he leads a large clinical and translational research program focused primarily on viral hepatitis and its complications.

Markus Cornberg

Professor Medizinische Hochschule Hannover

Markus Cornberg is Professor Infectious Diseases with a focus on Hepatology and Deputy Director of the Department of Gastroenterology, Hepatology and Endocrinology at Hannover Medical School, Germany. Since 2019, he is Clinical Director Helmholtz Centre for Infection Research and Director of the Centre for Individualized Infection Medicine (CIIM). Prof. Cornberg is Medical Executive Director of the German Liver Foundation. Since 2007, Prof. Cornberg has coordinated the German guideline on the management of hepatitis B virus infection. He has been Associate Editor of the Journal of Hepatology since 2019. His basic science research focus is the investigation of cellular immune responses for disease progression and treatment response in patients with viral hepatitis. Prof. Cornberg has published >300 original scientific papers as well as review articles.

Massimo Pinzani

Institute for Liver and Digestive Health University College London

Massimo Pinzani is Professor of Medicine at University College London (UCL), London, United Kingdom. He is a clinical and translational hepatologist, Sheila Sherlock Chair of Hepatology and Director of the UCL Institute for Liver and Digestive Health, Division of Medicine. He is one of the pioneers in the research dedicated to cellular and molecular mechanisms of liver fibrosis and relative diagnostic and therapeutic approaches. Current research is centred on regenerative medicine and on the development of extracellular matrix scaffold of liver, pancreas and small intestine for cell bioengineering and 3D disease modelling.
Professor Pinzani research activity is summarised in 298 original peer-reviewed publications (H Index of 104, Scopus). He has served in the governing and scientific boards of major international organization in Hepatology and Gastroenterology, and as Editor in Chief and Associate Editor of top peer reviewed international journals in Gastroenterology and Hepatology. He served as Educational Councillor and member of the governing board of the European Association for the Study of the Liver (EASL). He is co-founder and Chair of SAB of Engitix Therapeutics Ltd, an UCL spin-off company dedicated to extracellular matrix-based drug discovery for tissue fibrosis and cancer in the liver and digestive system.

Edward Gane

Professor of Medicine University pf Auckland

Dr. Gane is Professor of Medicine at the University of Auckland, and Deputy Director of the New Zealand Liver Unit at Auckland City Hospital. Dr. Gane trained in hepatology at the Institute of Liver Studies, King’s College School of Medicine, London. Dr Gane chairs the New Zealand Hepatitis B and C Elimination Strategies. Dr. Gane is an investigator for many international clinical trials on new therapies for viral hepatitis and has published over 500 papers in peer-reviewed journals. He has been awarded many awards from the New Zealand Health Research Council (Beaven and Liley Medals) and received Member of the Order of New Zealand for Services to Medicine.

Carla Coffin

Professor of Medicine University of Calgary

Carla S. Coffin, MD, MSc, FRCPC Professor of Medicine Cumming School of Medicine President-Elect Canadian Association for the Association of the Liver Medical Director of the Viral Hepatitis Clinic, Calgary Liver Unit, Division of Gastroenterology and Hepatology Coordinating Centre Canadian HBV Network.

https://canadianhbvnetwork.ca/

Marina Berenguer

Responsible of the Liver Transplantation/Hepatology Unit La Fe University Hospital

Professor of Medicine in the Department of Medicine at the University of Valencia and Responsible of the Hepatology and Liver Transplantation Unit in La Fe University Hospital. Past ILTS President in 2021-2022.

Maud Lemoine

Professor of Hepatology Imperial College London

Maud Lemoine is Professor and Consultant of Hepatology at St Mary’s hospital, Imperial College London. She is leading a research programme on prevention and management of chronic hepatitis B in Africa (www.prolifica.africa)

Olav Dalgard

Professor Akershus University Hospital

Olav Dalgard is a professorof infectious diseases. His research focus has been on health in people who inject drugs. In recent years Dalgard has been testing new models of hepatitis C care adapted to the special needs of people who inject drugs. Furthermore, he has done investigations of reinfection after succesful HCV treatment

Mark Thursz

Head of Department MDR Imperial College

Mark Thursz is professor of hepatology in the Division of Digestive Diseases and Head of the Department of Metabolism, Digestion & Reproduction in the Faculty of Medicine at Imperial College London. He is chief investigator for the NUC-B trial (funded by NIHR-EME) and initiated the (Prevention of Liver Fibrosis and Cancer) PROLIFICA Programme for hepatitis patients in Sub-Saharan Africa. Prof Thursz was Secretary-General of the European Association for Study of the Liver 2011-13. He is currently Director of the Imperial College Biomedical Research Centre and Trust Research Director for Imperial College Healthcare NHS Trust

Alessio Aghemo

Professor of Gastroenterology Humanitas University

Prof Aghemo is full professor of Gastroenterology and director of the postgraduate residency program for digestive system diseases at Humanitas University. He is the Head of the Division of Hepatology and Internal Medicine at Humanitas Research Hospital. Prof Aghemo has served as a member of Scientific Committee of the European Association for the Study of the Liver and the United European Gastroenterology Association. He is the Co Editor in Chief of Liver International. He has published more than 280 papers in peer reviewed journals.

Xavier Forns

Senior Consultant Liver Diseases. Professor Hospital Clinic. University Barcelona

Senior Consultant in Liver Diseases at Hospital Clínic. More than 300 piblications in the field of Viral Hepatitis, with particular expertise in the mangement of patients with advanced liver disease and liver transplant recipients. Former member of the EASL GB and Secretary of the Spanish Liver Association.

Darius Moradpour

Professor of Medicine and Chief of Service Lausanne University Hospital and University of Lausanne

Darius Moradpour is a Professor of Medicine at the University of Lausanne and the Chief of the Service of Gastroenterology and Hepatology of Lausanne University Hospital (CHUV). His research interests include the molecular virology and pathogenesis of hepatitis C and E as well as clinical and translational studies in viral hepatitis and other liver diseases.

Jacques Izopet

Deputy Director INFINITY - Toulouse Institute for Infections and Inflammatory Diseases

Jacques Izopet is Professor of Virology at Toulouse University and head of the Virology laboratory at Toulouse University Hospital. He is director of the National Reference Center for hepatitis E virus (HEV). He is deputy director of the Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY) research Center of Toulouse – INSERM UMR1291 / CNRS UMR5051. He is also head of a research team in this center. This team is interested in viral persistence, host response and pathophysiology. His research is focussed on HIV tropism, HEV and more recently SARS-Cov-2, in immunocompetent and immunocompromised patients. He has published over 650 papers in international journals.

David Thomas

Professor Johns Hopkins Medicine

Dr. Thomas is the Stanhope Bayne-Jones Professor of Medicine and Former Director of Infectious Diseases at Johns Hopkins University. He has a longstanding research interest in viral hepatitis especially in persons co-infected with HIV and in socially disadvantaged populations.

Jessica Hicks

Director World Hepatitis Alliance

Jessica Hicks is Director at the World Hepatitis Alliance. She has over 10 years’ experience working within the charity health sector, both within the UK and globally. Throughout her career she has focussed on working with organisations that support vulnerable populations and is on the advisory board of hepBcommunity.org, a forum for people living with hepatitis B. Jessica has expertise in developing and delivering community led programmes at global, regional and local levels and global advocacy campaigns.

George Papatheodoridis

Professor Medical School of National and Kapodistrian University of Athens

George Papatheodoridis is Professor in Medicine and Gastroenterology of the Medical School of National and Kapodistrian University of Athens and Director of Gastroenterology Department of “Laiko” General Hospital of Athens, Greece. He is also President of the Hellenic Transplant Organization. He was member of EASL Scientific Committee/Governing Board (2010-2013) and co-ordinator (2011-2012) and member (2016-2017) of EASL HBV Guidelines. He is a member of the EASL HDV Guidelines (2022). He has (co-)authored >400 PubMed papers having total IF >3000 and >25000/35000 citations (h-index:67/86) in Scopus/Google Scholar.

Harry Janssen

Director Section Liver Disease & Transplantation Erasmus MC, University Medical Center Rotterdam

Harry L.A. Janssen graduated from medical school in Nijmegen, Netherlands. During his study he spent one year as research fellow in Hepatology at the Mayo Clinic. He obtained his PhD at the Erasmus University in Rotterdam on the role of immune modulating therapy in chronic hepatitis B. Following his training in Internal Medicine in Leiden and Gastroenterology at the Erasmus University in Rotterdam, he returned to the Mayo Clinic for a Research Fellowship in Hepatology at the Center of Basic Research in Digestive Diseases. In 2001 he became a faculty member and in 2006 he was appointed as full Professor of Hepatology at the Erasmus University and Chief of the Section Liver Diseases and Transplantation at the Erasmus MC in Rotterdam. After a successful career in Rotterdam, he moved in 2013 to Toronto to become Chief of Hepatology at University Health Network and Professor of Medicine at the University of Toronto, where he also held the Francis Family Chair in Hepatology. In 2016 he merged all three Toronto Liver Programs into the Toronto Centre for Liver Disease to become the biggest liver program in North America, based at Toronto General Hospital. In 2022 dr. Janssen returned as a Professor of Medicine to the Erasmus MC in Rotterdam, Netherlands.

Man-Fung Yuen

Chair Professor The University of Hong Kong

Professor Yuen is now the Chair and Chief of the Division of Gastroenterology and Hepatology in the University of Hong Kong. He obtained his first bachelor degree of medicine in 1992. He further pursued his academic excellence through the achievement of obtaining 3 doctoral degrees including Doctor of Medicine with Sir Patrick Manson Gold Medal in 2001, Doctor of Philosophy in 2005 and Doctor of Science in 2017. Professor Yuen’s research interests include prevention, natural history, serology, virology and treatment of chronic hepatitis B and C, and hepatocellular carcinoma. He is one of the top internationally renowned researchers in the field of hepatitis B disease. He has now published more than 520 papers in world renowned medical journals including New England Journal of Medicine, Lancet, Nature Medicine, Lancet Infectious Diseases, Lancet Oncology. As a world-class clinician scientist, Professor Yuen is now leading most of the international trials examining new drugs including antiviral and immunomodulatory agents for the treatment of chronic hepatitis B. He is also actively performing cutting edge research on novel markers for hepatitis B infection and occult hepatitis B infection. With all these international academic and professional achievements, Professor Yuen is an invited member serving as key opinion leader for several international coalition committees on hepatitis B disease.

Carolyn Wester

Director, Division of Viral Hepatitis US Centers for Disease Control and Prevention

Carolyn Wester, MD, MPH, serves as the Director of the Division of Viral Hepatitis in the National Center for HIV, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) within the U.S. Centers for Disease Control and Prevention. In this role, she oversees the design and implementation of national programs for viral hepatitis prevention, control, surveillance and outbreak response. Prior to this role, Dr. Wester held positions as the Medical Director for HIV, STDs, and Viral Hepatitis at the Tennessee Department of Health, a Research Associate at the Harvard T.H. Chan School of Public Health, and the Director of Urogynecology and Pelvic Reconstructive Surgery section at Cook County Hospital in Chicago. Dr. Wester received her Medical Degree from Dartmouth Geisel School of Medicine and a Master of Public Health from Harvard’s T.H. Chan School of Public Health.

John Dillon

Professor of Hepatology School of Medicine, University of Dundee, UK.

Prof John Dillon is Professor of Hepatology and Gastroenterology in the Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee. He is also an Honorary Consultant with NHS Tayside, leading a busy general hepatology service. He is Vice President for Hepatology of the British Society of Gastroenterology and past President of the Scottish Society of Gastroenterology. He graduated in medicine from St Georges Hospital Medical School, University of London.

Maura Dandri

UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF

Maura Dandri is full Professor at the University Medical Center Hamburg-Eppendorf (UKE), in Germany, where she leads the Research Group Viral Hepatitis. She received her PhD in Microbiology & Immunology at the University of Trieste, Italy. She had a Postdoctoral training at Albert Einstein College of Medicine, New York. Since 2009 she leads the Research Group Viral Hepatitis at UKE in Hamburg. She is member of the Executive Board of the German Center for Infection Research (DZIF) and of the Governing Board of the International Coalition to Eliminate HBV (ICE-HBV). Her research interest mainly focuses on investigating virus-host interplay and the potential of novel therapeutic strategies, in particular against HBV and HDV using humanized mice and patient biopsy samples.

Stephan Urban

Universitätsprofessor University Hospital Heidelberg, Department of Infectious Diseases, Molecular Virology, Translational Virology

Professor Stephan Urban is head of the Translational Virology unit at the Department of Infectious Diseases, Molecular Virology at Heidelberg University Hospital. Between 2008 and 2012 he was Project coordinator of the BMBF-network “Innovative Therapies” and is now coordinating the Hepatitis D project within the DZIF TTU Hepatitis. He completed a Diploma in Biochemistry at the University of Tübingen in 1991 and was awarded a Ph.D. in 1995 under Prof. Dr. P.H. Hofschneider Max-Planck-Institut für Biochemie, Martinsried. He undertook Postdoctoral research at the Centre for Molecular Biology (ZMBH), Heidelberg University with Prof. Dr. H. Schaller. Following his PostDoc he became an independent group leader position, funded by the CHS Foundation. Professor Urban’s research interests include Molecular mechanisms of Hepatitis B- and Hepatitis D Virus/host interactions with a focus on the early and late events of viral infection; Identification of hepadnaviral receptors and structural analyses of virus receptor interactions; Development of novel cell culture systems and animal models for HBV and HDV; Development of bulevirtide/ Hepcludex; Development of hepatotropic drugs for the therapy of liver diseases; Innate Immune response on HBV and HDV viruses. Professor Urban has published in numerous peer reviewed journals on Hepatitis B, C and D. He is the recipient of the Pettenkofer Price of the Pettenkofer Foundation. He was awarded with the 1. DZIF Research Award (2014), the Distinguished Award in Hepatitis B Research (in 2021) and the Wolfgang-Gerok-Preis (in 2022).

Barbara Testoni

PI Cancer Research Center of Lyon - Inserm U1052

Barbara Testoni is a PI in the “Viral Hepatitis” team at CRCL – INSERM U1052 in Lyon. Her research interests mainly include the investigation of the epigenetic mechanisms at the basis of host and viral gene regulation during HBV infection, with particular focus on the transcriptional regulation of the HBV minichromosome. She is also involved in translational studies, to the aim of understanding the relationships between HBV persistence and intrahepatic innate immunity perturbations and to characterizing new serum biomarkers for intrahepatic cccDNA activity. She is an active member of the International Coalition to Eliminate HBV (ICE-HBV) and member of the Emerging Scientific and Medical Advisory Board (eSMAB) of the Hepatitis B Foundation.

Bruno Sangro

Director, Liver Unit Clinica Universidad de Navarra

Prof. Bruno Sangro is Director of the Liver Unit and Co-Director of the HPB Oncology Area at Clínica Universidad de Navarra in Pamplona, Spain. He is also Professor of Internal Medicine and leads an active research group in the Spanish Network for Biomedical Research on Hepatic and Digestive Diseases (CIBEREHD), focused on therapeutic innovation in the field of liver cancer.

Stephen Chan Lam

Professor Department of Clinical Oncology, The Chinese University of Hong Kong

Dr. Chan is currently the Professor at the Department of Clinical Oncology of the Chinese University of Hong Kong. His main interest of research is clinical and translational studies on hepatobiliary cancers. Internationally, he is serving as the Associate Editor for the Journal of Hepatology, and the chairman of the education committee of the International Liver Cancer Association (ILCA). Prof. Chan has published over 200 peer-reviewed papers, with young investigator award and gold medal dissertation award by the Hong Kong College of Physician.

Eleanor Barnes

Professor of Hepatology and Experimental medicine Oxford University

Ellie Barnes is Professor of Hepatology and Experimental Medicine, University of Oxford. She has a long-standing interest in hepatotrophic viruses, viral pathogenesis, immunology and vaccine development. She leads early human experimental medicine studies with the aims of developing a prophylactic HCV vaccine, including 2nd generation HCV vaccines based on conserved viral genomes, and constructs that encode genetic adjuvants with the potential for wide applicability in cancer and infectious disease. She is developing a program in HBV using simian adenoviral vectored vaccines with check point inhibitors for HBV immunotherapy (now in phase II efficacy testing).

Daniel Douek

Senior Investigator NIH

Daniel Douek is a Senior Investigator and Chief of the Human Immunology Section at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases, National Institutes of Health. He is also Chief of the Genome Analysis Core and Director of the PREMISE pandemic preparedness program. He also holds the position of Adjunct Professor at the Department of Pathology of the University of Pennsylvania. Dr. Douek studied medicine at the Universities of Oxford and London receiving academic scholarships from both institutions, and earning his MD in 1990. Dr. Douek studies the processes that determine the course of human infectious diseases in which the immune system plays a central role in their pathogenesis and outcome. These include HIV, SARS-CoV-2 and other diseases of pandemic potential.

Andrea Cox

Professor of Medicine and Oncology Johns Hopkins University

Dr. Cox’s laboratory investigates human immune responses to HCV, HBV, SARS-CoV-2, and HIV, including mechanisms through which these infections stimulate and evade immune responses, and in HCV vaccine development. She is also the co-director of the Johns Hopkins SARS-CoV-2 Pathogenesis and Immunity Center. As a member of the Viral Hepatitis Center in the Division of Infectious Diseases, she specializes in the treatment of patients with viruses including hepatitis virus infections and HIV. She was the principal investigator on the first prophylactic HCV vaccine trial ever implemented in an at-risk population, and is the lead immunologist on an ACTG trial of HBV vaccines in people living with HIV.

Ulrike Protzer

Institute Director Technical University of Munich / Helmholtz Munich

Ulrike Protzer is an expert virologist with many years of research in molecular virology, virus-host interaction and immunology. Ulrike studied medicine in Germany, South Africa and Switzerland. She has a strong background in infectious diseases, hepatology and medical virology obtained during her clinical training, and has passed board exams in Internal Medicine as well as in Microbiology and Virology. Since 2007, Ulrike Protzer is director of the Institutes of Virology at Helmholtz Munich and at the Technical University of Munich (TUM) and holds the Chair of Virology. Focusing on the promotion of young scientists, she serves as vice dean of the School of Medicine. 2011-2018 she was member of the founding executive board of the German Center for Infection Research. Currently, she is leading several national and international research consortia and serves in numerous advisory and supervisory boards. Her scientific efforts focus on understanding the interaction between viruses and their human hosts and on translating this knowledge into novel therapeutic approaches. Hereby, she focusses on the hepatitis B virus killing >880.000 humans every year and most recently on the new SARS-Coronavirus. Her group is exploiting vaccines and immune therapies to reconstitute HBV-specific immunity and finally cure HBV, and performs a number of clinical studies on the effect of SARS-CoV-2 infection and COVID-19 vaccines.

Pierre Van Damme

Full professor Universiteit antwerpen

Pierre Van Damme is heading the Centre for the Evaluation of Vaccination at the University of Antwerps since more than 30 years. He is full professor in vaccinology and infectious disease epoidemiology sinde more than 20 years. Pierre Van Damme became the executive secretary of the Viral Hepatitis Prevention Board in 1994 and is the chair of the WHO EURO hepatitis B working group since a few years. He is member of the Belgian NITAG, and advisor to national and international health orgnaizations.

Herbert Tilg

Director Medical University Innsbruck

Herbert Tilg is Head of Department of Gastroenterology, Hepatology & Endocrinology at Medical University Innsbruck, Austria. He did his research fellowship at Tufts University with Charles Dinarello. His research focus is inflammation and cytokine research in gastrointestinal disorders. He served as member of Governing Board of ECCO, EASL and UEG. He has been Chairman of the Scientific Committee of UEG.

Adam Gehring

Biology Lead Toronto Centre for Liver Disease

Dr. Gehring is the Biology Lead at the Toronto Center for Liver Disease and Assistant Professor in the Department of Immunology at the University of Toronto. He runs a translational, human HBV immunology research lab focused on liver pathogenesis and sex-based differences in disease progression. His primary interest lies in defining the mechanisms driving liver inflammation during HBV-related flares using functional and transcriptomic approaches in liver biopsies. His centre runs an immune monitoring core to process and analyze immune responses in Phase 1/2 clinical studies for novel therapeutic agents targeting HBV.

Augusto Villanueva

Associate Professor Icahn School of Medicine at Mount Sinai

Augusto Villanueva is Associate Professor in Icahn School of Medicine at Mount Sinai, New York. He received his medical degree from the University of Santiago de Compostela (Spain). Prior to his current position, he was Senior Lecturer and Consultant Hepatologist at the Institute of Liver Studies at King’s College Hospital (London) where he led Research and Development. He currently combines clinical activity as a hepatologist with research focused on understanding the role of intratumor heterogeneity in cancer evolution, and the development of novel minimally invasive biomarkers using liquid biopsy. He has more than 145 publications (Scopus >20,000 citations, H-index 62) including articles in N Engl J Med, Nat Genet, Nat Biotech, Nat Commun, Gastroenterology, Hepatology, J Hepatol, Gut, J Clin Invest, Oncogene, etc. He wrote more than 15 book chapters and edited a book on resistance to targeted therapies in HCC. He served as Associate Editor for J Hepatol and Liver Cancer and he is the Executive Secretary of the International Liver Cancer Association.

Tim Greten

Senior Investigator National Cancer Institute

Dr. Greten is a physician-scientist who uses his medical expertise in Gastroenterology, Hepatology and Medical Oncology along with his research expertise in tumor immunology to develop novel treatments for patients with cancer. He heads a research team to study the tumor microenvironment in the liver in the context of Hepatocellular Carcinoma, Cholangiocarcinoma, and liver metastasis. He also studies how exogenous factors such as diet and the gut microbiome may affect immune responses in the liver. He conducts clinical trials in patients with GI cancers and is co-director of the NCI CCR Liver Cancer Program

Laurent Castera

Professor of Hepatology Hopital Beaujon, AP-HP, Université Paris Cité

Laurent is Professor of Medicine at the University of Paris (Department of Hepatology, Beaujon University hospital, Assistance Publique – Hôpitaux de Paris, Clichy, France). His research interests focus on non-invasive methods for liver fibrosis assessment and epidemiology and treatment of nonalcoholic fatty liver disease. He has been the chairman of the first international EASL-ALEH guidelines on the use of non-invasive tests published in 2015. He has served as Secretary General for EASL from 2015 to 2017. He currently serves as Associate Editor for Clinical Gastroenterology and Hepatology journal.

Sunil Solomon

Associate Professor of Medicine and Epidemiology Johns Hopkins University School of Medicine

Sunil Suhas Solomon, MBBS PhD MPH is an Associate Professor of Medicine and Epidemiology in the Division of Infectious Diseases at the Johns Hopkins University School of Medicine. He completed his medical training at the Sri Ramachandra Medical University in Chennai, India and received a Masters in Public Health and a doctorate in Epidemiology (PhD) from the Johns Hopkins University, USA. Dr. Solomon has been elected into the Phi Beta Kappa and the Delta Omega honors societies. His research is primarily focused on the epidemiology, clinical management and access to care for HIV and viral hepatitis among vulnerable populations including people who inject drugs and men who sex with men. He has been working with PWID in India since 2004 and has over 140 original peer-reviewed publications in several high-ranked journals.

Naranjargal Dashdorj

CEO Liver Center

Dr. Naranjargal Dashdorj is Head of Liver Center and Onom Foundation in Mongolia. As the head of these organisations Nara has the challenging but exciting job to contribute in reducing liver disease disease burden in Mongolia. With her leadership, Onom Foundation initiated and playing a key role in shaping the Hepatitis Prevention, Control and Elimination Program of Mongolia (HPCE program). Nara holds a Degree in Medicine from Peking University Health Science Center, Beijing, China, and a Ph.D. from Nottingham University, Nottingham, United Kingdom.

Georg Lauer

Associate Professor of Medicine Massachusetts General Hospital/Harvard Medical School

Georg Lauer studied medicine in Tübingen, Hamburg, and Bochum, Germany. After clinical training, he moved to Boston for a fellowship in HCV T-cell immunology under Bruce Walker. His own lab is also located at MGH and HMS and he continues to study antigen-specific T cells in human infections in different acute and chronic infectious diseases. His scientific interests include HBV infection, specifically the direct ex vivo analysis of HBV-specific CD4 and CD8 T-cells from liver and blood in order to elucidate the characteristics of protective responses associated with functional cure.

Jake Liang

Chief National Institutes of Health

Dr. Liang is currently the Chief of Liver Diseases Branch and Deputy Director of Translational Research, NIDDK, and NIH Distinguished Investigator. He has published extensively on viral hepatitis and liver diseases, and has served as Associate Editor for pre-eminent GI journals. His outstanding contributions have been recognized with numerous awards. He is an elected member of the US National Academy of Medicine.

Florence Lacaille

Consultant Hôpital Necker-Enfants malades

I am a paediatrician trained in the most beautiful city in the world (Paris !). I traveled afterwards to Montreal, Canada, for a fellowship in Paediatric Gastroenterology, Hepatology and Nutrition, to discover the New World, the mysteries of my new speciality, and a glimpse of Science (they gave me a Master of…). Back in Paris, I established the unit of paediatric hepatology and liver transplantation in Necker-Enfants malades in 1992, where I have since been working with pleasure and multiple collaborations. I also am responsible for intestinal transplantation. I sat on the Council of ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology and Nutrition) and ITA (Intestinal Transplant Association), and am currently chairperson of the Young Investigator Forum (YIF) of ESPGHAN.

Christophe Rodriguez

Professor in virology APHP/INSERM

Christophe Rodriguez is professor in virology at University of Paris-Est-Creteil (France), works in the department of microbiology and in the French national reference center for hepatitis B, C delta. He is head of the Medical Reference Laboratory for metagenomics and head of NGS laboratory. Specialized in viral adaptation, he developed NGS diagnostic test and software for documentation of infection and prediction of outcome of patients (more than 10 patent). The NGS technology developed is currently used in diagnostic routine, accredited for bacterial, fungal, parasitic and viral pathogens according to the standard 15189 and used for more than 1500 diagnostic per year to explore complex infectious diseases. Its activity is now focused on the diagnostic of new pathogens, pathogens of undiagnosed diseases or complex cases of resistance and use of transcriptomic data in complement to Shotgun Metagenomic. He is the author of more than 100 publications.

Jason Grebely

Professor The Kirby Institute, UNSW Sydney

Jason Grebely is a Professor and Head of the Hepatitis C and Drug Use Research Group at the Kirby Institute, UNSW Sydney.

Jeffrey Lazarus

Professor Barcelona Institute for Global Health (ISGlobal)

Prof Jeffrey V. Lazarus (PhD, MIH, MA) is the head of the Health Systems Research Group at ISGlobal and Associate Professor at the University of Barcelona as well as a senior scholar at the CUNY Graduate School of Public Health and Health Policy. He is well known for his work on people-centred health systems and for launching the micro-elimination approach in hepatitis C elimination efforts. He currently serves as co-chair of the HIV Outcomes Beyond Viral Suppression coalition, a member of the board of directors of the SHARE Global Health Foundation and as a member of the EASL Public Health and Policy Committee and the Global NASH Council and is part of the ICE-HBV, ACHIEVE (in Europe) and AEHVE (in Spain) viral hepatitis elimination coalitions as well as the technical advisory group of Coalition for Global Hepatitis Elimination.

Slim Fourati

Full Professor HOSPITAL HENRI MONDOR - Virology Department

Pr Slim Fourati, MD, PhD, is a Professor in Clinical Virology and university lecturer at the Henri Mondor Hospital, Paris-Est University and INSERM U955 in Créteil, France. His research focus on HCV drug resistance and on respiratory viruses. He is currently leading the French National Hepatitis antiviral resistance group within the National Agency for Research on AIDS and Viral Hepatitis (ANRS).

Juan Pablo Arab

Associate Professor of Medicine - Transplant Hepatologist Western University

Dr. Arab is Associate Professor of Medicine at the Division of Gastroenterology, Department of Medicine, and the Department of Epidemiology and Biostatistics at Schulich School of Medicine, Western University, London, Ontario, Canada. Trained at the Pontificia Universidad Catolica, Chile and Mayo Clinic, Rochester, MN, USA. He has published more than 150 peer-reviewed papers, co-authored several book chapters and delivered lectures on liver-related topics at national and international meetings. He is an Associate Editor for Hepatology (flagship AASLD journal) and Social Media Editor. Dr. Arab is member of the AASLD Global Outreach and Engagement Committee. He is currently the Vice-Chair of the Special Interest Group on alcohol-associated liver disease of the AASLD.

Fasiha Kanwal

Professor and Chief of Section of Gastroenterology and Hepatology Baylor College of Medicine

Dr. Fasiha Kanwal is a Professor of Medicine and Chief of Gastroenterology and Hepatology at Baylor College of Medicine. She is a nationally recognized authority in health services research and epidemiology of cirrhosis and hepatocellular cancer (HCC). Currently, she is leading a translational research center for the National Cancer Institute Consortium on Translational Research in Early Detection of Liver Cancer (TLC, U01). She also serves as co-PI for the Texas HCC Consortium (THCCC) and as one of the co-Directors for the Texas Collaborative Center for HCC (TeCH). She is also the Director for NIH T32 funded GI fellowship program at Baylor College of Medicine.

Gamal Esmat

Cairo University Hospitals

Professor of Hepatogastroenterology & Infectious Diseases, Past Vice President of Cairo University, Egypt, Egyptian Nile Award in Science 2016, State Merit Award in Medical Science 2010, WHO STAC Member and Past President of International Association for Study of Liver Diseases

Stéphane Chevaliez

Full professor Henri Mondor University hospital

Stéphane Chevaliez is Professor of Medicine at the University of Paris-Est in Paris. He is also Director of the National Reference Center for Viral Hepatitis B, C and delta, a medical virologist in the department of Virology, and a member of INSERM Unit U955. Professor Chevaliez earned his pharmacy degree and PhD in virology at the University of Paris-Saclay and at the Pasteur Institute in Paris. Subsequently, he completed a postdoctoral fellowship in the Department of Gastroenterology and Hepatology at Massachusetts General Hospital, Boston, USA. Professor Chevaliez’s research interests include the diagnosis and virological monitoring of chronic viral hepatitis, and the development of novel therapeutic treatments. More recently he has focused on the molecular mechanisms underlying the success and failure (including viral resistance) of HBV, HCV and HDV treatment, as well as the development of alternative approaches to venous puncture for screening and diagnosis of viral hepatitis. Professor Chevaliez is the President of the Concerted Action 43 of the French National Agency for Research on AIDS and viral Hepatitis (ANRS-MIE).

Terry Cheuk-Fung Yip

Assistant Professor The Chinese University of Hong Kong

Terry Yip is an Assistant Professor in the Department of Medicine and Therapeutics at The Chinese University of Hong Kong. Terry’s research interest is big data approaches and risk prediction in patients with chronic liver diseases. He is an Associate Editor of Journal of Hepatology, and Frontiers in Gastroenterology Hepatology; and an Editorial Board member of Clinical Gastroenterology and Hepatology (CGH), Alimentary Pharmacology & Therapeutics (AP&T), Hepatology Communications, and Hepatoma Research. He has over 120 publications in peer-reviewed journals.

Seng Gee Lim

Director of Hepatology National University Health System

My main interest is in translational research in viral hepatitis, involving molecular biology and immunology of hepatitis B, new therapeutics and leads HBV Cure program in Singapore. He has published >274 peer review papers and has received >USD 35M in funding. He is on multiple editorial boards and advisory boards

Ahmed Elsharkawy

Consultant Hepatologist University Hospitals Birmingham NHS Trust

Ahmed Elsharkawy has been a Consultant Hepatologist since 2012. He has a specialist interest in viral hepatitis especially its elimination, liver transplantation, liver fibrosis, sarcopaenia, polycystic liver disease and ACLF. He is the clinical lead of the BASL Specialist Interest Group in Hepatitis B as well as being the Internal Affairs Councillor on the EASL Governing Board. He is also the EASL Social Media Advisor.

Elliot Tapper

Associate Professor University of Michigan Medical Center

Elliot B. Tapper MD is an Associate Professor in the Division of Gastroenterology and Hepatology where he directs the Michigan Cirrhosis Program. His research, funded by NIH, PCORI, and Industry focuses on improving quality of life for people with cirrhosis. He founded the online community called #LiverTwitter and is Editor-in-Chief of Hepatology Communications

Philipp Schwabl

Junior Professor Medical University of Vienna

Member of the EASL-Young Investigator Task Force Junior Professor at the Medical University of Vienna Research focus: Translational aspects of end stage liver disease and portal hypertension

Adam Zlotnick

Professor Indiana University

Adam Zlotnick is a Professor of Molecular and Cellular Biochemistry at Indiana University. He earned his PhD at Purdue University and was a post-doc at the NIH.A broad goal of his research is to relate the structure of virus capsid proteins to their self-assembly, with a focus on the core protein of Hepatitis B Virus. The opening line of his lab web site reads: “We take viruses apart. We put them back together. We make them make mistakes.” To translate his research into therapeutics he co-founded Assembly Biosciences (2012) in and Door Pharmaceuticals (2018). Dr. Zlotnick is also a fellow of the American Academy of Microbiology and of the American Association for the Advancement of Science.

Alexander Thompson

Director of Gastroenterology St Vincent’s Hospital and the University of Melbourne

Alexander Thompson is a Director of the Department of Gastroenterology at St Vincent’s Hospital and the University of Melbourne, Australia, NHMRC Practitioner Fellow and Adjunct Assistant Professor of the Department of Gastroenterology, Duke University Medical Center. Professor Thompson is the lead hepatologist for the Statewide Prison Hepatitis Service in Victoria, Australia. He is a current board member of the Gastroenterology Society of Australia, and former executive council member of the Asia Pacific Association for the Study of the Liver. His research focusses on improving outcomes for people living with viral hepatitis. He was involved in the discovery of IL28B polymorphism as a predictor of treatment outcome in HCV, and is an active clinical investigator for trials evaluating the efficacy of novel antiviral DAA regimens. With the development of DAA therapy for HCV, he has more recently been actively pursuing the development and evaluation of new models of care for people with HCV, with a focus on prisoners and treatment as prevention to eliminate transmission and reduce prevalence of HCV in Australia. Professor Thompson has published widely in journals including Nature, New England Journal of Medicine, Journal of the American Medical Association, Gastroenterology, Hepatology, Gut and Journal of Hepatology.

Anders Boyd

Biostatistician/Senior researcher Public Health Service of Amsterdam/HIV Monitoring Foundation

Anders received his PhD at the Université Pierre et Marie Curie in Epidemiology and Biostatistics. His research has focused on statistical applications towards numerous disease etiologies, including HIV, sexually transmitted infections, infectious disease prevention and psychosocial health. His work in viral hepatitis, in particular, has revolved around longitudinal models to study liver fibrosis progression and functional cure in individuals with HIV and HBV. Anders continues to work on larger monitoring databases for individuals with chronic viral infections.

Julien Calderaro

Henri Mondor Henri Mondor

Pr Julien Calderaro is Full Professor in the Department of Pathology of Henri Mondor University Hospital in Créteil, France. He is specialized in the field of liver diseases and tumors diagnosis. His works noticeably led to the establishment of a refined morphomolecular classification of liver cancer. He now focuses his research on the immune micro-environment of liver cancers and develops innovative, artificial-intelligence based approaches to extract meaningful prognostic and molecular data from digital histological slides.

Homie Razavi

Managing Director Center for Disease Analysis Foundation

Dr. Homie Razavi is the Managing Director and founder of the CDA Foundation, a non-profit organization dedicated to hepatitis elimination. He is also a fellow in the Society of Decision Professionals and has 25 years of decision analysis experience in healthcare, pharmaceuticals, and agriculture. In the last 10 years, he has focused his efforts on supporting public health decisions related to viral hepatitis elimination. He and his team collaborate with over 100 countries globally to develop and implement national programs. In addition, he started the Polaris Observatory which has become the gold standard in global and country-level HBV and HCV burden estimates. Homie is currently working on making hepatitis elimination feasible through innovative demonstration projects and financing mechanisms. He has over 120 peer-reviewed publications in Lancet, JAMA, J of Hepatology, and other high impact journals.

Thomas Pietschmann

Director of the Institute for Experimental Virology Twincore - Centre for Experimental and Clinical Infection Research

Since 2012 Full Professorof Experimental Virology at the Medical School Hannover and Director of the Institute of Experimental Virology at TWINCORE – Centre for Experimental and Clinical Infection

1997-2000 PhD degree at the Institute for Virology of the University of Würzburg 2012-2017 ERC starting grant “VIRAFRONT”

2002-2006 Postdoctoral fellow, University of Heidelberg, Heidelberg, Germany. Prof. Dr. Ralf Bartenschlager

Since 2021 Program-Oriented Funding IV speaker of the Helmholtz Centre of Infection Research (HZI) (period 2021-2027)

Since 2020 Member of the DFG Study Section FK 204 (Microbiology, Virology and Immunology)

Since 2019 German Center for Infection Research (DZIF) – Partner Site Speaker Hanover-Brunswick

Since 2019 Member of the DZIF internal advisory board

Since 2014 Member of the Advisory Board of the German Society of Virology

2018 – 2021 Speaker of the Junior Academy of the German Society of Virology

Jean Dubuisson

Head of Laboratory Center for Infection & Immunity of Lille

Jean Dubuisson is head of the Center for Infection & Immunity of Lille. He graduated as a veterinarian in 1984 from the University of Liège in Belgium, and he received his PhD degree in 1989 from the same university. He did a post-doctoral training between 1991 and 1994 at Washington University in St. Louis, USA, under the supervision of Charlie Rice, where he initiated research projects on HCV. In 1994, he obtained a tenure position at the CNRS and he started to develop his own group in France, at the Institut Pasteur de Lille, with the support of the CNRS.

Johan Neyts

Professor University of Leuven (KU Leuven)

Johan Neyts (www.antivirals.be) is professor of Virology at the University of Leuven (KU Leuven) in Belgium where he teaches virology. His lab has a long-standing expertise in the development of antiviral strategies against various viruses, including HCV and emerging and neglected viral infections such as dengue, Chikungunya, enteroviruses, rabies, HEV… Since 2020 the team made major contributions to research on SARS-CoV2. A second focus of the lab is the development of a novel vaccine technology platform technology based on the yellow fever vaccine virus as a vector. Four classes of antivirals discovered in his laboratory have been licensed to major pharmaceutical companies (against HCV, dengue, enteroviruses and RSV). Johan is a past-president of the International Society for Antiviral Research. He published ~630 papers [H-index: WoS 76 – Google Scholar 98], gave ~300 invited lectures and hundreds of lay-press interviews.

Mala Maini

Group leader UCL

Mala Maini is a Professor of Viral Immunology in the Division of Infection and Immunity at UCL, London and a Consultant Physician in the viral hepatitis clinic. Her lab researches liver immunity and immunopathology, focusing on cellular interactions in the liver niche. By dissecting the immune correlates of viral persistence versus control, the Maini lab contributes to the development of novel immunotherapeutic strategies for hepatitis B and hepatocellular carcinoma. Mala was awarded Wellcome Trust Senior Investigator Awards in 2013 and 2019 and elected to the Academy of Medical Sciences in 2016. Work in the Maini lab is also funded by the Cancer Research UK, EU Horizon 2020, Medical Research Foundation, NIHR, UKRI, British Infection Association.

Josep Llovet

Professor of Medicine - Translational research in hepatic oncology group leader IDIBAPS-Hospital Clínic

Josep M. Llovet, MD, PhD is Professor of Medicine – Hepatic Oncology at University of Barcelona, Professor of Research-ICREA in the Liver Unit, IDIBAPS-Hospital Clínic of Barcelona and Director of the Liver Cancer Program and Full Professor of Medicine at the Icahn School of Medicine at Mount Sinai, New York and Director. Professor Llovet obtained his degree in Medicine and Surgery from the University of Barcelona in 1986 and his PhD from the Autonomous University of Barcelona in 1995.
Professor Llovet has been President, Secretary and Founder of the International Liver Cancer Association (ILCA) Chairman of the European Clinical Practice Guidelines of management of liver cancer (EASL-EORTC), President of the AASLD-SIG of Hepatobiliary neoplasia and member of the Educational Committee of EASL. He has published more than 335 articles in peer-reviewed journals (total citations 131,899, total impact factor 8,221.9; h index 138-Google Scholar), > 55 chapters of books, and has delivered more than 620 lectures. He is Senior Editor of Clinical Cancer Research and has been recognized as Top-1% cited researcher in Clarivate Analytics (2014 to 2022).
He has devoted his career studying the pathogenesis and treatment of liver cancer. His clinical research contributed to the establishment of sorafenib, regorafenib, ramucirumab and chemoembolization as the standard of care in hepatocellular carcinoma (HCC). His group discovered novel drivers as therapeutic targets and described the molecular and inflamed classes HCC. He has received the AACR-Landon International Award (2009), the International Hans Popper award (2012), and was recognized as Fellow of the American Association for the Study of Liver Diseases (FAASLD-2015). He has received competitive funding for 95 projects, including the European Commission and the US National Institute of Health.